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Cancer research

Phototherapy Integrated Chemotherapy Offers Promising Cancer Treatment Strategy

Strategic Insights

— 2 min read

Researchers at Jiangsu University have explored the effectiveness of combining phototherapy with chemotherapy as a treatment strategy for cancer. According to their study, this approach, known as Phototherapy Integrated Chemotherapy (PIC), has shown promising results in eliminating cancer cells while minimizing toxic side effects. The study, supported by the National Natural Science Foundation of China and the Jiangsu Provincial Department of Science and Technology, utilized nondestructive real-time impedance spectroscopy to monitor cancer cell response and identified an optimal light exposure time of 60 minutes. The research demonstrated that mild phototherapy significantly enhanced chemotherapy, particularly with Lenvatinib in liver cancer cell treatments.

Key Takeaways:

  • Phototherapy Integrated Chemotherapy (PIC) offers a promising cancer treatment strategy due to its ability to target cancer cells more effectively and reduce toxic side effects.
  • The study identified an optimal light exposure time of 60 minutes for mild phototherapy, which enhances chemotherapy and improves cancer cell elimination.
  • Nondestructive real-time impedance spectroscopy was used to monitor cancer cell response, achieving a high correlation of 92.45% with standard methods.
  • The research proposed a new photochemical interaction mechanism, the 'more light-aiding, less bonding (LALB) mechanism,' which explains the enhanced effectiveness of mild phototherapy in combination with chemotherapy.
  • PIC combines the benefits of phototherapy and chemotherapy, providing a new strategy for cancer treatment and potentially promoting the development of advanced biomedical applications.
  • The study's findings suggest that mild phototherapy can be used to enhance the effectiveness of chemotherapy, particularly with Lenvatinib in liver cancer cell treatments.
  • The research was supported by the National Natural Science Foundation of China and the Jiangsu Provincial Department of Science and Technology.

Statistics:

  • 92.45% correlation between impedance measurements and standard methods of cancer cell response.
  • 99.82% correlation between standardized methods and impedance measurements of cancer cell viability and resistibility.
  • The study utilized nondestructive real-time impedance spectroscopy to monitor cancer cell response.
  • The research identified an optimal light exposure time of 60 minutes for mild phototherapy.
  • The proposed 'more light-aiding, less bonding (LALB) mechanism' explains the enhanced effectiveness of mild phototherapy in combination with chemotherapy.

Sources:

  • Advanced Science, 2025.
  • Shihui Wang, School of Electrical and Information Engineering, Jiangsu University, Zhenjiang, 212000, People's Republic of China.
  • Tongge Li, Qianhui Ling, Junyi Sun, Ning Yang, Zhanglei Fu, Zhaoyuan Zhang, Si Chen, Yanfei Wang, Ni Yu, Yafei Wang, Zhexuan Ding, Haodong Liu, Yanwei Jia, Yifang Wang, and Xingcai Zhang.
  • National Natural Science Foundation of China.
  • Jiangsu Provincial Department of Science and Technology.
  • Wiley, 111 River St, Hoboken 07030-5774, NJ, USA.

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