Cancer
Researchers at the College of Pharmacy have successfully designed a near-infrared light-induced transformative nanoparticle platform that combines photothermal ablation with immunotherapy to effectively treat cancer. The innovative approach, known as photothermal immunotherapy, has shown promising results in treating both primary and distant tumors in a mouse breast cancer model. The
Cancer
Research published in the Gastric Cancer journal revealed significant differences in gene expression levels among specific sites of primary tumors and synchronous lymph node metastases in advanced gastric cancer patients. The study analyzed 48 patients' specimens, obtained through laser-captured microdissection, to determine the expression levels of six target genes:
Cancer
Researchers from Sun Yat Sen University have conducted a study to evaluate the significance of epigenetic changes in Epstein-Barr virus-associated gastric carcinoma (EBVaGC). The study analyzed 49 EBVaGC tissue samples and 45 EBV-negative gastric carcinoma (EBVnGC) tissue samples, as well as cell lines, to determine the promoter methylation status and
Cancer
Researchers have shed new light on the molecular pathogenesis of nasopharyngeal carcinoma (NPC) and gastric cancer (GC) associated with Epstein-Barr virus (EBV). The virus is known to be involved in nearly all cases of NPC and approximately 10% of GC worldwide. Studies have shown that EBV contributes to the initiation
Cancer
Research conducted at the University of Pittsburgh has shed light on the regulatory mechanism of the anti-apoptotic protein Mcl-1 in gastric cancer cells, revealing a novel target for enhancing sensitivity to oxaliplatin. The study found that Forkhead box M1 (FOXM1) expression levels were positively correlated with Mcl-1 expression, both of
Cancer
A breakthrough in cancer treatment has been patented, utilizing a fusion protein that targets angiogenesis, a crucial process in cancer growth. The patent, filed on July 25, 2012, and published on March 24, 2015, is assigned to Samsung Electronics Co., Ltd. and details a novel approach to treating cancer using
Cancer
A new approach to combat the growing global burden of cancer is being explored by researchers, leveraging the human genome project to develop molecular-targeted treatments. The world is facing an increasing number of new cancer cases, predominantly in developing countries, which demands a more comprehensive and integrated approach to cancer
Cancer
Cancer cells have been found to modify their nuclear architecture and transcriptional control, which enables them to grow and metastasize. Research at Mayo Clinic has identified RUNX family transcriptional scaffolding proteins as key factors in this process. Proteomic analysis revealed that RUNX2 interacts with three distinct proteins that respond to
Cancer
Recent breakthroughs in biotechnology have enabled the rapid identification of target genes, paving the way for gene and nucleic acid therapy as the next generation of medicine. This evolving field has led to significant interest in nanoparticle-based anticancer gene therapy treatment, which shows promise in improving gene transfection efficiencies. Researchers
Cancer
Researchers at the Institute for Cancer Research and Treatment (IRCCS) in Milan, Italy, have developed biodegradable polymeric nanoparticles that demonstrate improved efficacy in treating malignant glioma compared to commercial reagents. The study, published in ACS Nano, highlights the potential of these nanoparticles for nonviral gene therapy in extending brain tumor
Cancer
Researchers at the University of Minnesota have developed the Candidate Cancer Gene Database (CCGD), a manually curated database of identified candidate driver genes and transposon common insertion sites from published transposon-based screens in mice. The database, available at http://ccgd-starrlab.oit.umn.edu/, aims to improve access to findings and
Cancer
Researchers at the National Cancer Institute have developed RNA and RNA/DNA-based nanoparticles designed to conditionally activate RNA interference in human cells. These nanoparticles demonstrate precise control over their formulation, stability in blood serum, and activation of multiple functionalities. The study, published in ACS Nano, found that DNA nanoparticles showed
