Cancer research
Genetic modifications play a crucial role in the development of cancer, with histone deacetylases (HDACs) emerging as key enzymes influencing gene expression. Histone deacetylase inhibitors (HDACis) are being developed as a novel category of anticancer agents, with suberoylanilide hydroxamic acid (SAHA) being the only FDA-approved HDACi for the treatment of
Cytological research
A recent study published in the Journal of Experimental & Clinical Cancer Research has investigated the effect of all-trans retinoic acid (ATRA) on the proliferation and differentiation of brain tumor stem cells (BTSCs). The research, conducted by Niu and colleagues in the People's Republic of China, aimed to
Cytological research
Researchers at the University of Washington, Fred Hutchinson Cancer Research Center, have investigated the impact of recipient statin treatment on graft-versus-host disease after allogeneic hematopoietic cell transplantation. The study, published in the journal Biology of Blood and Marrow Transplantation, analyzed outcomes among 1206 patients with hematologic malignancies who underwent hematopoietic
Cancer research
Scientists in the United States have published a study revealing that etoposide inhibits the proliferation of SK-N-AS neuroblastoma cancer cells and promotes protein kinase Cdelta (PKCdelta)- and caspase-dependent apoptosis. The study found that etoposide induces the caspase-3-dependent cleavage of PKCdelta to its active p40 fragment, leading to a positive-feedback
Cancer research
Scientists at Harbin Medical University in China have made a significant discovery in the fight against gastric cancer. In a recent study, they found that FTY720, a new immunosuppressant, has the potential to inhibit the growth of gastric cancer cells. The researchers discovered that FTY720 induces a significant increase of
Cancer research
Researchers at Seattle Genetics, Inc. have discovered that the auristatin-based anti-CD70 antibody-drug conjugate SGN-75 can effectively target pancreatic and ovarian carcinomas. CD70, a protein highly expressed in renal carcinomas and non-Hodgkin lymphomas, has been identified as an ideal target for antibody-based therapies. Scientists generated murine monoclonal antibodies specific for CD70
Cancer research
Scientists from the United States have made new findings in DNA research, specifically regarding the role of myosin VI in tumor cells exposed to DNA damage. According to a study published in the Journal of Biological Chemistry, myosin VI is a motor protein that plays a crucial role in various
Cancer research
Researchers at the University of Oxford have made significant discoveries in the field of cancer gene therapy, particularly in the regulation and effects of Hypoxia-Inducible Factor (HIF) on Ewing's sarcoma and osteosarcoma. The study, published in Bmc Cancer, sheds light on the expression and function of HIF in
Cancer research
Researchers at the University of California, Department of Radiation Oncology, have conducted a study on the irradiation of potential cancer stem cell niches in the adult brain, which may improve progression-free survival of patients with malignant glioma. The study, published in Bmc Cancer, found that higher radiation doses to the
Cancer research
Cancer remains a leading cause of death worldwide, especially among patients undergoing immunosuppressive therapy. Research has shown that calcineurin inhibitors (CNIs) can promote tumor growth and induce the overexpression of angiogenic cytokines like VEGF. A recent study investigated whether CNIs can alter VEGF mRNA stability in renal cancer cells, revealing
Cancer research
Research published in the International Journal of Cancer has revealed that alpha5beta1 integrin antagonists may be a new therapeutic target for glioblastoma, a type of malignant brain tumor known for its resistance to conventional therapies. The study found that inhibiting alpha5beta1 integrin with specific nonpeptidic antagonists can decrease chemotherapy-induced premature
Cancer research
Recent research published in the journal Cancer Science has shed light on the role of DNA methylation of interferon regulatory factors (IRFs) in the tumorigenesis of gastric cancer. The study found that epigenetic inactivation of IRF4, IRF5, and IRF8 was frequently observed in gastric cancer cell lines, and that methylation
