Cancer
Devoted Birmingham dad Jack Ricketts bravely battled lymphoblastic lymphoma, a rare form of cancer, after it was discovered during scans when he was 26. His condition worsened, and he was placed into a coma in hospital. With his family by his side, Jack wrote "goodbye notes" for his
Cancer
Among 399 cancer survivors in China who received radiotherapy or chemotherapy, researchers found distinct self-management profiles for oral mucositis. The study, conducted at Zibo Central Hospital, aimed to investigate self-management status and predictors among cancer survivors in China. The results highlighted three categories of self-management ability: Low Level-Negative, Medium Level-Relatively,
Cancer
Researchers at Chongqing University Cancer Hospital have developed a machine learning-based early warning system to predict venous thromboembolism (VTE) in lymphoma patients undergoing chemotherapy. The system, known as VTE-EWS, uses 12 clinical variables and six machine learning algorithms to identify patients at high risk of VTE. According to a new
Cancer
A recent multi-institutional study has analyzed 39 cases of anaplastic lymphoma kinase-positive large B-cell lymphoma (ALK+ LBCL), a rare and aggressive subtype of diffuse large B-cell lymphoma with poor outcomes using standard chemotherapy. Researchers from the University of Texas MD Anderson Cancer Center found that despite conventional cytotoxic regimens, outcomes
Cancer
Ashley Davies, a 30-year-old NHS worker, tied the knot with her partner Steven Thomas last weekend at the Towers Hotel in Swansea. The wedding was a special occasion for the couple, but more so for Ashley's mother Kelly, who was undergoing treatment for mucinous ovarian cancer, a rare
Cancer
Researchers from the Indian Institute of Technology Kharagpur have revealed the potential of virgin coconut oil (VCO) and its lauric acid (LA) as adjuvant therapeutic agents in cancer management. The study, published in the Journal of Xenobiotics, highlights the pharmacological activities of VCO and LA in combating chronic pathologies, infectious
Cancer
MIT chemists have developed a new targeted cancer therapy using tiny particles called nanoparticles that can deliver a large range of chemotherapy drugs directly to tumor cells. The new therapy, which is guided by antibodies that target specific tumor proteins, uses bottlebrush-shaped polymer chains carrying dozens or hundreds of drug
Cancer
Researchers from Georgetown University Medical Center have conducted parallel phase II clinical trials to evaluate the efficacy and safety of selinexor, an inhibitor of the nuclear receptor exportin-1 (XPO1/CRM1), in patients with advanced thymoma and thymic carcinoma. The trials, which enrolled 31 patients, demonstrated modest anticancer activity with limited
Cancer
Akeso's global partner, Summit Therapeutics, has announced updated overall survival (OS) results from the global Phase III HARMONi clinical trial of ivonescimab, a novel PD-1/VEGF bispecific antibody. The results demonstrate a consistent and robust clinical efficacy in both progression-free survival (PFS) and OS across diverse global populations.
Cancer
A new analysis from the COMPEL trial presents evidence that patients with EGFR-mutated non-small cell lung cancer (NSCLC) who experienced non-central nervous system (CNS) progression on first-line osimertinib can benefit from continuing osimertinib treatment in combination with platinum-based chemotherapy. The study found that median progression-free survival was 8.4 months
Cancer
Researchers at Koc University have published a new study on exocytosis, a process that plays a crucial role in cell signaling and the sequestering of toxins, including chemotherapeutic agents. The study found that epigenetic changes drive gene expression alterations, contributing to oncogenesis and drug resistance. The researchers screened over 150
Cancer
Researchers at Nanjing Medical University have made a significant breakthrough in the treatment of gastric cancer. By developing quercetin-loaded Ti3C2Tx MXene nanosheets (MX-Que), the team aimed to achieve synergistic chemo-photothermal therapy against gastric cancer. The nanosheets demonstrated high photothermal conversion efficiency under near-infrared (NIR) irradiation, leading to increased ROS production,
