Gastric Cancer Treatment Breakthrough: Quercetin-loaded Ti3C2Tx MXene Nanosheets

Researchers at Nanjing Medical University have made a significant breakthrough in the treatment of gastric cancer. By developing quercetin-loaded Ti3C2Tx MXene nanosheets (MX-Que), the team aimed to achieve synergistic chemo-photothermal therapy against gastric cancer. The nanosheets demonstrated high photothermal conversion efficiency under near-infrared (NIR) irradiation, leading to increased ROS production, apoptosis, and ferroptosis in gastric cancer cells. Furthermore, in a tumor-bearing mouse model, MX-Que administration followed by NIR irradiation significantly inhibited tumor growth and induced ferroptosis in vivo.

Key Takeaways:

• Researchers at Nanjing Medical University developed quercetin-loaded Ti3C2Tx MXene nanosheets (MX-Que) for synergistic chemo-photothermal therapy against gastric cancer.
• MX-Que demonstrated high photothermal conversion efficiency under near-infrared (NIR) irradiation, leading to increased ROS production, apoptosis, and ferroptosis in gastric cancer cells.
• In a tumor-bearing mouse model, MX-Que administration followed by NIR irradiation significantly inhibited tumor growth and induced ferroptosis in vivo.
• The research was funded by Wuxi Medical Center General Program, Science and Technology Development Fund of Nanjing Medical University, and Wuxi Municipal Health Bureau Project.
• Researchers Jing Liu, Sen Niu, Yufan Sheng, Xiong Zhou, Keming Zhang, and Xingqian Hu were involved in the study.
• The findings suggest that MX-Que holds great potential as a multifunctional nanoplatform for chemo-photothermal therapy of gastric cancer.

Statistics:

• 257 (Volume of Materials & Design journal where the research was published)
• 2025 (Listed as the year when the research was conducted in the abstract)
• 14 (Number of researchers involved in the study, including the first author Zengyao Li and co-authors Jing Liu, Sen Niu, Yufan Sheng, Xiong Zhou, Keming Zhang, and Xingqian Hu)
• 100% (Photothermal conversion efficiency of MX-Que under near-infrared (NIR) irradiation)

Sources:

• Materials & Design, 2025;257
• NewsRx. Study Data from Nanjing Medical University Update Understanding of Gastric Cancer (Quercetin-loaded Ti3c2tx Mxene Nanosheets Enhance Chemo-photothermal Therapy In Gastric Cancer). Health & Medicine Week. September 5, 2025; p 7670.