COVID-19
Researchers at the University of Cincinnati have shed light on the mechanism of action of Molnupiravir, one of the two recently approved oral COVID-19 therapeutics. The study found that Molnupiravir is hydrolytically activated by CES2, a major hydrolase whose activity is impacted by genetic polymorphic variants, disease mediators, and potentially
COVID-19
Pediatric solid organ transplant recipients are at a higher risk of developing severe COVID-19 complications due to their compromised immune systems. A new study conducted by researchers at Stanford University has investigated the effectiveness of the SARS-CoV-2 vaccine in this population. The study found that after three doses of the
COVID-19
Researchers from Public Health England have conducted a study to examine the symptoms experienced by children with COVID-19. According to the findings, most children recover quickly from the virus, but some may experience ongoing symptoms. The study, which used national testing data, identified 1,500 PCR-positive cases and 1,500
COVID-19
Regeneron Pharmaceuticals Inc. researchers have published new report on the combined role of anti-viral monoclonal antibodies and vaccines in reducing SARS-CoV-2 transmission and mortality in the United States. Their research, published in Clinical Pharmacology & Therapeutics, aimed to assess the impact of these interventions on pandemic transmission and mortality during
COVID-19
Researchers from the University of Massachusetts conducted a study to evaluate the transfer of immune responses from lactating women who received the COVID-19 mRNA-based vaccine to their breastfeeding infants. The study consisted of 30 lactating women who received the vaccine from January through April 2021. The results showed that the
COVID-19
A recent study published in the American Journal of Epidemiology has found significant racial disparities in the accuracy of pulse oximeters, a device used to measure blood oxygen saturation, among individuals with darker skin pigmentation. The research analyzed data from Sutter Health, a large healthcare delivery system in northern California,
COVID-19
A Japanese study reported a rare case of cytokine release syndrome (CRS) following COVID-19 vaccination in a patient with non-small cell lung cancer undergoing immunotherapy. The patient experienced high fever, consciousness loss, and brain inflammation after the third vaccination, which improved dramatically after steroid therapy. Researchers warn clinicians to be
COVID-19
Research from the University Teaching Hospital in Caen, France, has found a significant association between certain COVID-19 vaccines and the rare neurological disorder, transverse myelitis (TM). The study, which analyzed data from the World Health Organization's pharmacovigilance database, VigiBase, found that mRNA-based and vector-based SARS-CoV-2 vaccines authorized by
COVID-19
The COVID-19 pandemic's effects on antimicrobial resistance in Japan are not yet fully understood, despite its significant impact on healthcare systems worldwide. New research has shed light on the pandemic's influence on microbial infections and related metrics in Japan. By analyzing data from the Japan Surveillance
COVID-19
Research from King Fahad Armed Forces Hospital in Saudi Arabia highlights the importance of hand hygiene practices (HHP) among pediatric physicians, with a focus on reducing the risk of infection during the COVID-19 pandemic. The study, which was conducted among 404 pediatric physicians, found that 56.68% were male and
COVID-19
Researchers from Virginia Commonwealth University have discovered a potential new approach to controlling type 2 diabetes and its associated cardiovascular complications using a combination of phosphodiesterase 5 (PDE5) inhibitors and hydroxychloroquine (HCQ). This novel therapy shows promise in reducing the rate and severity of COVID-19 infection in vulnerable populations, such
COVID-19
Researchers at Johns Hopkins University have developed a novel approach to identify pathogenic autoreactive antibodies associated with severe COVID-19. By using genome-scale libraries of full-length proteins covalently coupled to unique DNA barcodes, the team was able to detect circulating neutralizing type-I and type-III interferon (IFN) autoantibodies in patient plasma. The
