Scientists
Researchers have made significant discoveries in the study of retinoic acid, a major component of vitamin A, in regards to its effects on skeletal muscle cells. The research, conducted by a team from Korea University's Department of Anatomy, found that retinoic acid activates AMP-activated protein kinase (AMPK), leading
Universities and colleges
Researchers at Nanjing University have recently published a study in Methods and Findings in Experimental and Clinical Pharmacology, uncovering the dual effects of arsenic trioxide (ATO) on acute promyelocytic leukemia (APL) cells. The study found that ATO preferentially induces apoptosis at high concentrations and promotes partial differentiation at low concentrations.
Cytological research
In a study published in Genes & Development, researchers from Syracuse University examined the checkpoint responses to rereplication in a developmental context using Drosophila. They found that increased Double-parked (Dup), the Drosophila ortholog of Cdt1, results in rereplication and DNA damage, which triggers caspase activation and apoptotic cell death in
Cytological research
Mitochondrial abnormalities have long been a topic of discussion in the scientific community when it comes to understanding the origins of cancer. A recent study from the United States, led by M.A. Kiebish and colleagues from Boston College, Department of Biology, sheds new light on this issue. The researchers
Universities and colleges
Researchers at Seoul National University have identified a key mechanism underlying the development of drug resistance in liver cancer cells infected with the hepatitis B virus (HBV). According to their study, published in Cancer Science, HBV expression in liver cancer cell lines induces resistance to the chemotherapeutic agent 5-fluorouracil (5-FU)
Universities and colleges
Recent research published in Clinical Cancer Research has identified a correlation between promoter methylation patterns in the N-methyl-D-aspartate receptor 2B (NMDAR2B) gene and poor prognosis in patients with esophageal squamous cell carcinoma (ESCC). The study, conducted by scientists in the United States, analyzed the methylation status of the NMDAR2B gene
Scientists
A recent study published in the journal Cancer Science has shed light on the potential benefits of soy isoflavones in treating adult T-cell leukemia. Researchers from Miyazaki University discovered that genistein, a type of soy isoflavone, exhibited biphasic growth-inhibitory properties, preventing the growth of cancer cells in both in vitro
Scientists
Scientists from Kingston University have made groundbreaking discoveries on the traditional medicine Oldenlandia diffusa, which has been used for centuries to treat various cancers. The research, published in the Journal of Ethnopharmacology, reveals that Oldenlandia diffusa exhibits a cytotoxic effect on leukaemic cells, inducing apoptosis in a cell cycle-independent fashion.
Universities and colleges
A new study published in the JARO - Journal of the Association for Research In Otolaryngology has found that heat shock can inhibit sensory hair cell death caused by ototoxic drugs. Sensory hair cells are responsible for human hearing and balance, and their death can lead to permanent impairments. The
Universities and colleges
A recent study from the United States sheds light on the complex functions of the CD8 coreceptor on T cells. Researchers at the University of Chicago found that the CD8 coreceptor has two distinct functions: stabilizing the binding of the T-cell receptor (TCR) to the peptide-MHC complex and localizing p56(
Scientists
Research conducted at the University of California has led to the discovery that oxidative stress can significantly increase the sensitivity of neural precursor cells to ionizing radiation. The study, published in the International Journal of Radiation Biology, found that cells subjected to increased oxidative stress through low-density growth or exogenous
Scientists
Researchers have discovered that NF-kappa B activation is a crucial factor in the transcriptional synergy of indoleamine dioxygenase (IDO) induced by IFN-gamma and tumor necrosis factor-alpha (TNF-alpha). The study, published in Cytokine, found that the expression of IRF-1, a transcriptional activator critical to IDO regulation, is enhanced synergistically in response
