Diseases
Parkinson's disease is a complex and multifaceted disorder that affects millions worldwide. Researchers have made significant strides in understanding the root causes of the disease, its progression, and potential treatment options. According to Jennifer Taylor, helpline service manager at Parkinson's UK, subtle changes in handwriting and
Diseases
Regeneron Pharmaceuticals has launched an interventional clinical trial, Phase 1, aimed at evaluating the safety, tolerability, pharmacokinetics, and pharmacodynamics of single ascending doses of intrathecally administered ALN-SNCA in participants with early Parkinson's disease. The trial, which is not yet open for recruiting, will involve 46 participants from the
Diseases
Scientists at Johns Hopkins Medicine have shown how mammalian brains create networks of tubes that transport toxins in and out of brain cells, similar to pneumatic tubes in factories and stores. This discovery, published in the journal Science, may advance understanding of the processes that lead to Alzheimer's
Diseases
Scientists at Viralgen, a subsidiary of AskBio acquired by Bayer in 2020, are dedicated to finding cures for diseases affecting a large number of people through cell and gene therapies (CGT). While Parkinson's disease is the most advanced program in Bayer's CGT pipeline, other priority diseases
Diseases
Research from Sunway University has associated a specific single nucleotide polymorphism (SNP) of the interleukin-13 (IL-13) gene, rs20541, with multiple chronic inflammatory diseases. While rs20541 has been linked to various immune-related conditions, its precise functional relevance in disease pathogenesis remains unclear. A meta-analysis of 45 case-control studies revealed consistent associations
Diseases
Research conducted at the University of Freiburg has unveiled significant insights into the relationship between age and biomarkers in Alzheimer's disease. Investigators from the university's Department of Nuclear Medicine analyzed data from 2,355 patients with Alzheimer's disease, shedding light on the divergent effects
Diseases
Patients with chronic conditions such as chronic obstructive pulmonary disease (COPD), dementia, and amyotrophic lateral sclerosis (ALS) often receive substandard palliative care compared to those with cancer, a recent study has shown. The research, conducted in Germany, analyzed claims data from 2016 to 2019 and found that non-oncological patients in
Diseases
A recent study conducted by researchers from the Poznan University of Medical Sciences in Poland has highlighted the potential link between climate change and the progression of coronary artery disease. The study, which analyzed data from 224 patients who underwent percutaneous coronary intervention (PCI) followed by repeated angiography, found that
Diseases
A recent study published in The Clinical Respiratory Journal has shed light on the relationship between neutrophil to lymphocyte ratio (NLR), red blood cell distribution width (RDW), and pulmonary hypertension (PH) in patients with bronchiectasis and chronic obstructive pulmonary disease overlap syndrome (BCOS). The research, conducted by a team of
Diseases
Shape Therapeutics, a leader in RNA-based gene therapy, has presented new preclinical data showcasing the therapeutic potential of its lead product, SHP-201, a disease-modifying gene therapy for the treatment of Parkinson's Disease (PD). The Company also presented data highlighting its novel BBB-penetrant, engineered AAV5 capsid, SHP-DB1, which efficiently
Diseases
Abeona Therapeutics Inc., a commercial-stage biopharmaceutical company, has announced that its ABO-503 gene therapy for X-linked retinoschisis (XLRS) has been selected for the U.S. Food and Drug Administration's (FDA) Rare Disease Endpoint Advancement (RDEA) Pilot Program. This program aims to support the development and timely approval of
Diseases
Researchers from Jeju National University have discovered that beta-alanine, a non-essential amino acid, can alleviate non-alcoholic fatty liver disease (NAFLD) in mice. The study, published in Toxicological Research, found that beta-alanine improved NAFLD by regulating hepatic sulfur-amino acid metabolism, reducing oxidative stress, and promoting fat export via very-low-density lipoprotein secretion.
