Sign in Subscribe
Diseases

New Study Reveals Correlation Between NLR, RDW, and Pulmonary Hypertension in BCOS Patients

Strategic Insights

— 2 min read

A recent study published in The Clinical Respiratory Journal has shed light on the relationship between neutrophil to lymphocyte ratio (NLR), red blood cell distribution width (RDW), and pulmonary hypertension (PH) in patients with bronchiectasis and chronic obstructive pulmonary disease overlap syndrome (BCOS). The research, conducted by a team of experts from Qilu Hospital of Shandong University, aimed to explore the indexes that can represent the severity of patients with BCOS overlapping PH.

The study analyzed the clinical data of 159 patients with BCOS admitted to Qilu Hospital of Shandong University Dezhou Hospital from January 2019 to November 2024. The results showed that the level of NLR and RDW in the experimental group (BCOS patients with PH) was higher than those in the control group (BCOS patients without PH), with statistically significant differences (p < 0.01). Furthermore, the study found that NLR and RDW were significantly correlated with pulmonary artery systolic blood pressure (PASP) in BCOS patients.

The key takeaways from this study are:

  • The NLR and RDW can serve as significantly relevant factors for pulmonary hypertension complicating BCOS.
  • The level of NLR and RDW in BCOS patients with PH was higher than those in BCOS patients without PH.
  • There was a significant correlation between NLR and RDW with PASP in BCOS patients.
  • The difference in NLR and RDW levels between the experimental and control groups was statistically significant (p < 0.01).
  • The study suggests that NLR and RDW can be used as indexes to represent the severity of patients with BCOS overlapping PH.
  • The results of the study have important implications for the diagnosis and treatment of BCOS-PH.

The statistics mentioned in the study are:

  • 159 patients with BCOS were included in the study.
  • 106 patients with BCOS-PH were in the experimental group.
  • 53 patients with BCOS without PH were in the control group.
  • The NLR and RDW levels in the experimental group were higher than those in the control group (p < 0.01).
  • The correlation coefficient between NLR and RDW with PASP in BCOS patients was 0.745.
  • The area under the ROC curve (AUC) for NLR and RDW in distinguishing between 'PH-complicated' and 'non-PH-complicated' statuses among BCOS patients was 0.946.

Sources:

  • The Correlation Between NLR, RDW, and Pulmonary Hypertension in Patients With Bronchiectasis and Chronic Obstructive Pulmonary Disease Overlap Syndrome. The Clinical Respiratory Journal, 2025;19(10).
  • Qilu Hospital of Shandong University Dezhou Hospital, Dezhou, People's Republic of China.
  • Wiley, 111 River St, Hoboken 07030-5774, NJ, USA.
  • NewsRx. New Chronic Obstructive Pulmonary Disease Study Findings Have Been Reported by Researchers at Qilu Hospital of Shandong University (The Correlation Between NLR, RDW, and Pulmonary Hypertension in Patients With Bronchiectasis and Chronic ...). Respiratory Therapeutics Week. October 13, 2025; p 2621.

Read more