Biochemistry
Researchers at the Affiliated Hospital of Guangdong Medical University have found that JS-K, a glutathione S-transferase-activated nitric oxide donor, can enhance the sensitivity of renal cancer cells to radiation therapy. Their study, published in Biomedicine & Pharmacotherapy, aimed to explore the potential of JS-K as a radiosensitizer for treating renal
Biochemistry
Researchers at the University Health Network in Toronto, Canada, have conducted a study to investigate the diversity and specificity of T cell receptor (TCR) sequences in patients with solid tumors treated with pembrolizumab. The study analyzed TCR sequences from tumor, peripheral blood mononuclear cell (PBMC), and cell-free DNA (cfDNA) samples
Genetic research
Researchers at Henan University of Science and Technology have made a groundbreaking discovery in the field of oncology, revealing a new DNA damage repair pathway in hepatocellular carcinoma cells. The study, published in Acta Biochimica et Biophysica Sinica, found that the combined treatment of L-arginine and 5-fluorouracil significantly inhibits cell
Genetic research
Researchers at Sogang University have developed a novel electrochemical sensor on a thermally controllable paper-based digital microfluidic (e-pDMF) device for detecting human papillomavirus type 16 DNA (HPV16 DNA). The e-pDMF device operates in transport and thermal modes to enable programmable droplet manipulation and precise temperature control, facilitating multiple processes from
Genetic research
Researchers at the Hospital for Sick Children have developed a new tool to personalize cancer screening for individuals with Li-Fraumeni syndrome, a genetic disorder that confers high lifetime cancer risk. The study, funded by the Terry Fox Research Institute and the Canadian government, found that a comprehensive surveillance regimen, the
Biochemistry
A team of researchers from University Hospital Montpellier has identified synthetic lethal combinations of DNA repair inhibitors and genotoxic agents that may improve treatment outcomes for patients with high-risk diffuse large B-cell lymphoma (DLBCL). According to their study published in Hematological Oncology, these combinations can induce cell death, DNA damage,
Genetic research
In a recent study, researchers at the University Hospital North Norway found that genotype-specific HPV mRNA triage can enhance risk stratification and improve detection efficiency for cervical intraepithelial neoplasia 2+ (CIN2+) compared to traditional cytology. The study, which analyzed data from 34,721 women aged 25-69, demonstrated that the HPV
Genetic research
Researchers from the Virginia Institute of Marine Science, in collaboration with colleagues, conducted a study to evaluate the efficacy of three vaccine regimens against infectious hematopoietic necrosis virus (IHNV) in rainbow trout. They assessed the protection against viral transmission using various delivery methods, including intramuscular injection, intraperitoneal injection, and bath
Genetic research
Investigators at the University of Strasbourg have pioneered a groundbreaking approach to monitoring plant biodiversity in large river systems. The research, led by Armando Espinosa Prieto, employed multi-marker environmental DNA metabarcoding to analyze aquatic and terrestrial plant diversity from river water samples. The innovative method successfully detected 24 aquatic plant
Genetic research
Researchers at Kyungpook National University have conducted a study to investigate the composition of DNA viruses in the hindgut contents of Protaetia brevitarsis larvae obtained from five different farms. The study focused on understanding the gut virome of insects and its implications for animal health and homeostasis. The research found
Genetic research
A recent study published in Discover Oncology aims to map the research landscape on circulating tumor DNA (ctDNA) for colorectal cancer. The study collected articles and reviews from the Web of Science Core Collection and Scopus databases, conducting bibliometric analysis and visualization using VOSviewer, CiteSpace, and R packages. The analysis
Genetic research
A new study has found that astronauts experience accelerated ageing, with cells losing their ability to make healthy new cells and becoming more prone to DNA damage. The University of California sent stem cells to the International Space Station to investigate the impact of low gravity, and the results were
