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Biochemistry

JS-K Enhances Renal Cell Carcinoma Radiosensitivity

Strategic Insights

— 2 min read

Researchers at the Affiliated Hospital of Guangdong Medical University have found that JS-K, a glutathione S-transferase-activated nitric oxide donor, can enhance the sensitivity of renal cancer cells to radiation therapy. Their study, published in Biomedicine & Pharmacotherapy, aimed to explore the potential of JS-K as a radiosensitizer for treating renal cell carcinoma (RCC). The findings suggest that JS-K can induce G2/M phase arrest, inhibit homologous recombination repair and the Wnt/b-catenin signaling pathway, and augment the radiosensitivity of renal cancer cells.

Key Takeaways:

  • JS-K has shown promising anti-tumor effects in various types of tumors, but research on its role in cancer radioresistance is limited.
  • The study investigated the effect of JS-K on the radiosensitivity of renal cancer cells and found that it can enhance the sensitivity of cells to radiation therapy.
  • JS-K induced G2/M phase arrest, inhibited homologous recombination repair and the Wnt/b-catenin signaling pathway, and augmented the radiosensitivity of renal cancer cells.
  • In vivo experimentation utilizing animal models supported the function of JS-K in augmenting the radiosensitivity of renal cancer cells.
  • Alterations in pertinent proteins were quantified by immunohistochemical analysis, confirming the potential of JS-K as a radiosensitizer for treating RCC.
  • The study highlights the potential of JS-K as a promising radiosensitizer for treating renal cell carcinoma.
  • The research was conducted at the Affiliated Hospital of Guangdong Medical University, with Xinghua Lin as the lead author.
  • Additional authors include Yuwan Zhao, Wenfeng Zeng, Lugang Zhu, Bailiang Miu, Xingzhang Qin, Sheng Gao, Jingping Qiu, Bin Li, Jianjun Liu, and Mushi Ye from the Laboratory of Urology.
  • The publisher of the journal is Elsevier France-editions Scientifiques Medicales Elsevier, 65 Rue Camille Desmoulins, CS50083, 92442 Issy-Les-Moulineaux, France.

Statistics:

  • 2025: The year in which the study was published.
  • September 16, 2025: The date on which the news report was published.
  • 191: The volume number of the Biomedicine & Pharmacotherapy journal in which the study was published.
  • 118514: The article number of the study in the Biomedicine & Pharmacotherapy journal.
  • 65 Rue Camille Desmoulins: The address of the publisher, Elsevier France-editions Scientifiques Medicales Elsevier.
  • CS50083: The postal code of the publisher, Elsevier France-editions Scientifiques Medicales Elsevier.
  • 92442 Issy-Les-Moulineaux, France: The city and postal code of the publisher, Elsevier France-editions Scientifiques Medicales Elsevier.

Sources:

  • Biomedicine & Pharmacotherapy, 2025;191:118514.
  • NewsRx. Data on Kidney Cancer Discussed by Researchers at Affiliated Hospital of Guangdong Medical University (JS-K enhances renal cell carcinoma radiosensitivity through the Wnt/b-catenin signaling pathway and inhibits DNA damage repair). Cancer Weekly. September 16, 2025; p 789.

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