Drugs
PR Pharmaceuticals Inc. (PRP) has successfully secured a U.S. patent for 2-methoxyestradiol (2ME), a compound that has demonstrated significant potential in treating diabetes and pulmonary arterial hypertension (PAH). The patent, assigned to the University of Pittsburgh, has been exclusively licensed to PRP, which is developing the drug, known as
Drugs
CytRx Corp. (CYTR) has made significant strides in its drug-discovery programs aimed at developing molecular medicines for obesity and type 2 diabetes using its proprietary RNA interference (RNAi) technologies. The company's high-throughput functional RNAi screening platform has discovered and validated approximately 30 new type 2 diabetes and obesity
Pharmaceutical industry
Avant Immunotherapeutics (AVAN) has achieved a significant milestone with the approval of Rotarix, a rotavirus vaccine, by the European Commission. This approval has led to a $4 million milestone payment from GlaxoSmithKline (GSK), marking a key event in the worldwide commercialization of Rotarix. According to Una S. Ryan, PhD, Avant&
Pharmaceutical industry
The U.S. Food and Drug Administration has approved ERBITUX (cetuximab), an IgG1 monoclonal antibody, for the treatment of squamous cell carcinoma of the head and neck. Developed by ImClone Systems Incorporated and Bristol-Myers Squibb Company, ERBITUX is the first and only monoclonal antibody to be approved for this indication.
Drugs
Scientists in Japan have conducted a study to investigate the effect of consuming pork-liver protein hydrolysate (PLH) on body fat accumulation in obese rats. The research, led by M. Shimizu and colleagues working with the Nippon Meat Packers, involved feeding male 20-week-old Otsuka Long-Evans Tokushima Fatty (OLETF) rats and Long-Evans
Drugs
Research from Japan, the Canada V6T 1Z3, and the United Kingdom has led to significant advances in diabetes therapy, with new findings on the efficacy and safety of various treatments. Key studies have shown that novel drugs such as KCP256 and dipeptidyl peptidase IV inhibitors can effectively manage diabetes without
Drugs
Researchers at the University of Seville in Spain have discovered that digitoxin, a cardiac glycoside, can inhibit cancer cell growth at concentrations commonly found in patients with cardiac disease. The study, published in the Journal of Natural Products, found that digitoxin was the most active compound in inhibiting growth in
Drugs
Pediatric cancer patients may benefit from new cancer therapies as research studies from the Netherlands, the United States, and Austria show promising results. Netherlands researchers found that pegfilgrastim, a long-lasting form of granulocyte colony-stimulating factor, can be safely administered to pediatric cancer patients to prevent neutropenia, a major side effect
Drugs
A novel study conducted by researchers at the Universite de Louvain in Brussels, Belgium, has found that the cosmetic treatment Botox may have a new use as an adjuvant to cancer therapy. Led by Bernard Gallez, PhD, professor of pharmacy, the study injected botulinum neurotoxin type A into two types
Drugs
Genentech's submission of a supplemental biologics license application (sBLA) to the U.S. Food and Drug Administration (FDA) for Herceptin in early-stage, HER2-positive breast cancer is based on a joint interim analysis of over 3000 patients from two phase III trials sponsored by the U.S. National Cancer
Drugs
Recent studies from the United States and the People's Republic of China have shed light on the complex molecular mechanisms underlying prostate cancer progression and metastasis. Three research studies have identified novel targets and therapeutic strategies that may offer new hopes for the treatment of this aggressive and
Drugs
Scientists have identified two CD8+ T-cell epitopes, VILTNPISM and FSNSTNDILI, from mouse VEGFR2 that can inhibit angiogenesis and tumor growth. These epitopes, discovered by researchers at the U.S. National Cancer Institute, were found to be effective in reducing angiogenesis and inhibiting tumor growth in mouse models. This discovery provides
