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Protein Hydrolysate Reduces Body Fat in Obese Rats

Strategic Insights

— 2 min read

Scientists in Japan have conducted a study to investigate the effect of consuming pork-liver protein hydrolysate (PLH) on body fat accumulation in obese rats. The research, led by M. Shimizu and colleagues working with the Nippon Meat Packers, involved feeding male 20-week-old Otsuka Long-Evans Tokushima Fatty (OLETF) rats and Long-Evans Tokushima Otsuka (LETO) rats a diet containing PLH or casein for 14 weeks. The study found that dietary PLH significantly reduced the growth and weight of fat pad in OLETF rats, suppressing hepatic activities of lipogenesis enzymes and slightly elevating fecal excretion of total fat.

Key Takeaways:

  • The study was conducted to examine the effect of consuming pork-liver protein hydrolysate (PLH) on body fat accumulation in obese rats, specifically Otsuka Long-Evans Tokushima Fatty (OLETF) rats.
  • M. Shimizu and colleagues fed 20-week-old OLETF and LETO rats a diet containing PLH or casein for 14 weeks to compare the effects on body fat accumulation.
  • Dietary PLH was found to significantly reduce the growth and weight of fat pad in OLETF rats, including perirenal and epididymal adipose tissues.
  • Consumption of PLH suppressed hepatic activities of lipogenesis enzymes such as glucose-6-phosphate dehydrogenase and fatty acid synthase.
  • Fecal excretion of total fat was also slightly elevated in OLETF rats consuming PLH.
  • In LETO rats, growth and adipose tissue weight were unaffected by dietary treatment.
  • The results suggest that PLH is a novel ingredient suppressing body fat in genetically obese rats by reducing lipogenesis.
  • Shimizu and colleagues published their study in Boscience Biotechnology and Biochemistry (Consumption of pork-liver protein hydrolysate reduces body fat in Otsuka Long-Evans Tokushima fatty rats by suppressing hepatic lipogenesis. Biosci Biotechnol Biochem, 2006;70(1):112-118).

Statistics:

  • 20-week-old OLETF and LETO rats were used in the study, which lasted for 14 weeks.
  • Dietary PLH or casein was provided to the rats for comparison of effects on body fat accumulation.
  • Weight of fat pad in OLETF rats consuming PLH was significantly reduced.
  • Hepatic activities of lipogenesis enzymes (glucose-6-phosphate dehydrogenase and fatty acid synthase) were suppressed in OLETF rats.
  • Fecal excretion of total fat was slightly elevated in OLETF rats consuming PLH.

Sources:

  • Shimizu, M., et al. (2006). Consumption of pork-liver protein hydrolysate reduces body fat in Otsuka Long-Evans Tokushima fatty rats by suppressing hepatic lipogenesis. Biosci Biotechnol Biochem, 70(1), 112-118.
  • Health & Medicine Week editors (2006). Protein Hydrolysate Reduces Body Fat in Obese Rats. Health & Medicine Week via NewsRx.com.

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