Genetic research
Researchers at Tsinghua University have developed a novel approach to gene expression in plants using mosaic viruses. By engineering the sugarcane mosaic virus (SCMV) as a dual gene expression vector, the team demonstrated its ability to efficiently express two heterologous proteins in maize plants. This breakthrough has significant implications for
Genetic research
In a significant breakthrough in the field of developmental origins of health and disease, a team of researchers has introduced RAMEN, a new framework for analyzing DNA methylation (DNAme) microarrays. RAMEN, which stands for Findable, Accessible, Interoperable, and Reusable, uses machine learning and statistical techniques to model and dissect gene-environment
Genetic research
Research conducted by scientists at Hajee Mohammad Danesh Science and Technology University in Dinajpur, Bangladesh, has uncovered significant evidence of the toxic effects of polystyrene microplastics (PS-MPs) on thyroid function in mice. The study, published in Veterinary Medicine and Science, found that exposure to PS-MPs led to substantial increases in
Genetic research
A recent study published in the Proceedings of the National Academy of Sciences has shed light on the mechanisms of the zinc finger antiviral protein (ZAP), an essential component of the innate immune response. Researchers from Imperial College London discovered that ZAP depletes nonself RNAs by recognizing their elevated CpG
Genetic research
Research published in the Marine Environmental Research journal has explored the impact of acute ammonia stress on the digestive physiology and gene expression in juvenile yellowfin tuna. The study found that different concentrations of ammonia nitrogen can affect the digestive activity of the fish, with ammonia levels below 5 mg/
Genetic research
Scientists at the Technical University Munich (TU Munich) have successfully developed a powerful strategy to accelerate bioprocess development using parallel bioreactor systems and automated RNA-Seq analysis. Their research, published in the journal Microorganisms, demonstrates the effectiveness of combining liquid handling stations with high-throughput experiments to gain a molecular understanding of
Genetic research
Researchers from Hefei University of Technology have published a new study on the phytochemical profiles of four Chaenomeles speciosa cultivars, focusing on the analysis of phenolic acids, flavonoids, organic acids, and triterpenoids. The study used high-performance liquid chromatography-mass spectrometry (HPLC-MS/MS) and RNA sequencing (RNA-seq) to quantify the phytochemicals and
Gene expression
AbbVie and ADARx Pharmaceuticals have announced a collaboration and license option agreement to develop small interfering RNA (siRNA) therapeutics across multiple disease areas, including neuroscience, immunology, and oncology. This partnership will leverage ADARx's RNA discovery expertise and proprietary siRNA technology, combined with AbbVie's expertise in antibody
Genetic research
Research suggests that over 373 risk genes play a significant role in the development of autism spectrum disorder (ASD) and developmental delay (DD). A recent study employed a pooled CRISPR approach to investigate the transcriptomic impacts of targeting 29 neurodevelopmental disorder (NDD) loss-of-function genes across various human cell types. The
Genetic research
Dr. W. Lee Kraus and his team at Cornell University have made a groundbreaking discovery that has left the scientific community abuzz. PARP-1, a cellular enzyme long known to biologists, has been found to play a pivotal role in gene transcription, opening up new possibilities for therapies in cancer and
Genetic research
A recent study published in the British Journal of Cancer found that loss of heterozygosity in the histidine triad gene intron 5 is linked to more severe cases of cervical cancer. Researchers assessed high-risk human papillomavirus, loss of heterozygosity on chromosome 3p, and fragile histidine triad gene expression in 83
