Loss of Heterozygosity in Histidine Triad Gene Linked to Severe Cervical Cancer Cases

A recent study published in the British Journal of Cancer found that loss of heterozygosity in the histidine triad gene intron 5 is linked to more severe cases of cervical cancer. Researchers assessed high-risk human papillomavirus, loss of heterozygosity on chromosome 3p, and fragile histidine triad gene expression in 83 cervical cancers and 74 cervical intraepithelial neoplasia grade 1 lesions. The study identified human papillomavirus type 16 as an indicator of vascular involvement in cancers, while loss of heterozygosity in the fragile histidine triad gene intron 5 was associated with high-grade tumors and greater tumor depth.

Key Takeaways:

• Loss of heterozygosity in the histidine triad gene intron 5 is a marker of high-grade cervical tumors and greater tumor depth.
• Human papillomavirus type 16 is an indicator of vascular involvement in cervical cancers.
• Abnormal fragile histidine triad gene expression is more frequent in cervical intraepithelial neoplasia grade 1 lesions with increased risk of disease progression.
• Loss of heterozygosity in the fragile histidine triad gene intron 5 is associated with lymph node involvement in cervical cancers.
• The study examined 83 cervical cancers and 74 cervical intraepithelial neoplasia grade 1 lesions.
• High-risk human papillomavirus was assessed as a potential marker of cancer and CIN progression.
• Fragile histidine triad gene expression was evaluated as a potential marker of cancer and CIN progression.
• The researchers noted that abnormal fragile histidine triad gene expression was more frequent in cervical intraepithelial neoplasia grade 1 lesions.

Statistics:

• 83 cases of cervical cancer were assessed in the study.
• 74 cases of cervical intraepithelial neoplasia grade 1 lesions were examined.
• High-risk human papillomavirus was detected in cervical cancers.
• Human papillomavirus type 16 was associated with vascular involvement in cervical cancers.
• 20% of cervical intraepithelial neoplasia grade 1 lesions had abnormal fragile histidine triad gene expression.

Sources:

• Terry G, et al. (2004). The role of human papillomavirus type 16 and the fragile histidine triad gene in the outcome of cervical neoplastic lesions. Brit J Cancer, 91(12), 2056-2062.
• Health & Medicine Week editors (2005, Health & Medicine Week via NewsRx.com & NewsRx.net).