Genetic research
Researchers from the National Institute of Infectious Diseases in Japan have developed a new safety assessment method for mRNA vaccines based on lung biomarker gene expression. The study, published in the journal Vaccine, examined the bioactivity and toxicity profiles of SARS-CoV-2 mRNA vaccines, including Spikevax and COMIRNATY. The researchers found
Endometriosis
Researchers at Islamic Azad University have made significant breakthroughs in understanding the genetic and demographic factors contributing to the incidence of endometriosis. The study published in the Middle East Fertility Society Journal aimed to investigate the relationship between gene expressions and demographic variables such as lifestyle factors, locality, and ethnicity
Epigenetic inheritance
A new study has shed light on the causes of heart failure, one of the leading causes of death worldwide. According to research published in the journal Nature Communications, cardiac remodeling processes, including the death of cardiac myocytes and their replacement by cardiac fibroblasts, contribute to heart failure. The study
Coronary heart disease
Current research published in a study from the University of Virginia has made significant progress in understanding the genetic basis of coronary artery disease (CAD). By conducting a comprehensive functional characterization of CAD-associated variants in primary vascular smooth muscle cells (SMCs), the researchers have identified 122 candidate variants with enhancer
Genes
Scientists at Washington University have developed a novel method to modulate protein translation efficiency, a key challenge in various fields of science and industry. The method involves modifying the nucleic acid sequence encoding a protein of interest to produce a modified nucleic acid sequence encoding a second protein. By making
Genes
Investigators at Boston Medical Center have identified gene expression changes related to mucus pathology in chronic obstructive pulmonary disease (COPD). According to a study published in the American Journal of Respiratory and Critical Care Medicine, researchers investigated the link between mucus plug formation and chronic bronchitis in 290 participants from
Genetic research
A new study has shed light on the causes of heart failure, one of the leading causes of death worldwide. According to research published in the journal Nature Communications, cardiac remodeling processes, including the death of cardiac myocytes and their replacement by cardiac fibroblasts, contribute to heart failure. The study
Genetic research
Scientists at Universite de Perpignan Via Domitia have made significant findings in the field of genetics, revealing a novel system that counteracts Polycomb silencing to promote gene expression. The research, published in Nature Plants, highlights the crucial role of plant mobile domain C protein-DNA motif modules in stabilizing gene expression.
Genetic research
Research on the evolution of gene expression responses has been ongoing, focusing on understanding how DNA sequence influences expression in response to variable environments. A recent study from Pennsylvania State University has shed light on this complex process, suggesting that flexible machine learning models can learn the underlying regulatory genotype
Genetic research
Researchers at Zhejiang Sci-Tech University have found that DNA methylation plays a critical role in regulating gene expression and secondary metabolism in plants. The study, published in The Plant Journal, analyzed the effects of DNA methylation on tanshinone production in Salvia miltiorrhiza and Salvia bowleyana, two traditional Chinese medicinal plants.
Genetic research
Recent research conducted by Biogen has shed light on the pharmacodynamic effects of litifilimab on type I interferon (IFN) response and its correlations with clinical outcomes in systemic lupus erythematosus (SLE) and cutaneous lupus erythematosus (CLE). The study, published in the journal Arthritis & Rheumatology, investigated the effects of litifilimab
Genetic research
Investigators at the Sapienza University of Rome have conducted a study comparing gene expression and cell biology in biopsy specimens from repaired and reconstructed anterior cruciate ligaments. The study aimed to understand the differences in cellular activity and gene expression between the two types of ligament reconstruction. The researchers collected
