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Genes

Novel Method for Modulating Protein Translation Efficiency

Strategic Insights

— 1 min read

Scientists at Washington University have developed a novel method to modulate protein translation efficiency, a key challenge in various fields of science and industry. The method involves modifying the nucleic acid sequence encoding a protein of interest to produce a modified nucleic acid sequence encoding a second protein. By making specific changes at codons 3, 4, and 5, the level of expression of the second protein can be increased or decreased compared to the first protein.

Key Takeaways:

  • The new method can modulate protein translation efficiency by modifying the nucleic acid sequence encoding a protein of interest.
  • The method involves inserting a polynucleotide sequence between specific codons 3, 4, and 5 to produce a modified nucleic acid sequence.
  • The level of expression of the second protein can be increased or decreased compared to the first protein.
  • The method can be used to alter the amino acid sequence of the protein of interest.
  • The claims of the patent include methods for increasing protein translation efficiency by inserting a polynucleotide sequence at different positions between codons 3, 4, and 5.
  • Specific polynucleotide sequences can be used to achieve the desired level of protein expression.
  • The inventor's background information highlights the need for alternative methods to modulate protein translation efficiency.

Statistics:

  • The patent was filed on August 7, 2019.
  • The patent was published online on September 30, 2025.
  • The claims of the patent include 4 specific methods for modulating protein translation efficiency.
  • The invention provides a novel method for modulating protein translation efficiency, which can be used in various fields of science and industry.
  • The level of expression of the second protein can be increased or decreased by up to 100% compared to the first protein.
  • The method can be used to produce proteins with desired properties at high levels.

Sources:

  • Djuranovic, Sergej. Methods to modulate protein translation efficiency. U.S. Patent Number 12428640, filed August 7, 2019, and published online on September 30, 2025. Patent URL (for desktop use only): https://ppubs.uspto.gov/pubwebapp/external.html?q=(12428640)&db=USPAT&type=ids
  • Journal of Engineering News Reporter-Staff News Editor. (2025). A patent by the inventors Djuranovic, Sergej (St. Louis, MO, US), filed on August 7, 2019, was published online on September 30, 2025, according to news reporting originating from Alexandria, Virginia, by VerticalNews correspondents.

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