Clinical trials
Research findings have shed light on the potential of oncolytic virotherapy in treating recurrent head and neck cancer. A recent study published in Virus Research has demonstrated the efficacy and safety of a novel therapeutic approach using VT1093, an oncolytic recombinant herpes simplex virus type 1 engineered to express a
Clinical trials
Research conducted by Genentech Inc.'s IQ DILI Initiative highlights the need for guidance in evaluating liver tests due to COVID-19, its treatments, and vaccination. The study emphasizes the variability of liver-related manifestations in non-hospitalized patients and the potential for liver injury to occur even after symptoms resolve. The
Genetic research
Researchers from Oxford Biomedica (UK) Ltd. have made a significant discovery in the field of gene therapy, detailing a new system that enhances the production and quality of lentiviral vectors. According to the study, the novel system, referred to as the TetraVecta System, utilizes optimized major-splice-donor-inactivating sequences and a new
Genetic research
Researchers at the Medical University of Bialystok in Poland have published a groundbreaking study on the role of neurotrophins in sensory processing in autism spectrum disorder (ASD). The study, published in the October 2025 issue of the journal Neuroscience, sheds light on the potential of gene therapy and other biotechnological
Genetic research
Researchers from Case Western Reserve University have made a significant breakthrough in the field of gene therapy, specifically in the area of hematopoietic stem cell expansion and engineering. According to a recent study published in the journal Stem Cells, the team has developed innovative strategies to recreate essential aspects of
Genetic research
Research from McMaster University has shed light on the persistence of anti-platelet factor 4 antibodies in patients with vaccine-induced immune thrombocytopenia and thrombosis (VITT). According to a study published in the Journal of Thrombosis and Haemostasis, a significant proportion of patients continue to test positive for these antibodies for nearly
Genetic research
Research at Nanjing University in Suzhou, People's Republic of China, has shed light on the evolving scientific landscape of CAR-T cell therapy for glioblastoma, a highly aggressive and lethal primary malignant brain tumor in adults. The study analyzed a comprehensive dataset of publications related to CAR-T cell therapy
Genetic research
Researchers from Sun Yat-sen University Cancer Center have made significant strides in developing a novel therapy for non-small cell lung cancer (NSCLC) by leveraging siRNA-based technology in conjunction with biomimetic nanovesicles. The study, published in the Journal of Nanobiotechnology, demonstrates the efficacy of this approach in modulating the tumor microenvironment
Genetic research
Research findings from Purdue University suggest that interleukin-27 (IL-27) cell-based gene therapy may be a viable treatment option for acute respiratory distress syndrome (ARDS). The study, which utilized a cell-based gene therapy approach, demonstrated the ability of IL-27-expressing plasmids to reduce pro-inflammatory gene expression and promote tissue repair in both
Genetic research
Research has identified the innate immune response as a major limitation to recombinant adeno-associated viruses (rAAV) used in gene delivery. A new study published in Molecular Therapy - Methods & Clinical Development has investigated the interaction between rAAV and the innate immune system, highlighting the mechanisms of complement activation and
Genetic research
Research has shown that cancer vaccines offer a promising approach to cancer prevention and treatment, leveraging the immune system to recognize and target tumor-specific or tumor-associated antigens. A recent study explores the diverse platforms and mechanisms supporting cancer vaccines, examining prophylactic and therapeutic options, and highlighting key barriers to vaccine
Genetic research
Recent research out of the University of Marburg has made significant strides in cancer gene therapy using lipid-based nanocarriers (LBNCs). Despite the challenges of conventional cancer treatments, these nanocarriers have emerged as a promising solution for delivering therapeutic RNA molecules. With the help of the Alexander von Humboldt Foundation and
