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Genetic research

Global Research Trends in CAR-T Cell Therapy for Glioblastoma

Strategic Insights

— 1 min read

Research at Nanjing University in Suzhou, People's Republic of China, has shed light on the evolving scientific landscape of CAR-T cell therapy for glioblastoma, a highly aggressive and lethal primary malignant brain tumor in adults. The study analyzed a comprehensive dataset of publications related to CAR-T cell therapy in GBM from inception to December 31, 2024, using the Web of Science Core Collection and CiteSpace. The findings revealed rapid growth in annual outputs starting in 2015, with the United States and China leading in productivity and collaboration.

Key Takeaways:

  • The research identified 303 relevant publications related to CAR-T cell therapy in GBM, showing a significant increase in annual outputs starting from 2015.
  • The United States and China were found to be the leading countries in terms of productivity and collaboration, with influential authors such as Christine E. Brown and Donald M. O'Rourke contributing significantly to the field.
  • Neuro-Oncology and Clinical Cancer Research emerged as key publishing and co-cited journals, highlighting the importance of these platforms in disseminating research findings in GBM.
  • Co-citation and keyword analysis revealed a shift from early focus on single-antigen CAR designs toward dual-target constructs, 'armored' CAR-T cells, and combinatorial immunotherapies.
  • Recent research hotspots included immunomodulation, precision medicine, and novel delivery platforms such as nanoparticles and oncolytic viruses.
  • The study maps the evolving scientific landscape of CAR-T cell therapy in GBM, highlighting key contributors, institutional collaboration, and emerging research frontiers.

Statistics:

  • 303 relevant publications related to CAR-T cell therapy in GBM were included in the analysis.
  • Annual outputs showed a significant increase starting from 2015, with the United States and China leading in productivity and collaboration.
  • Predicted bursty keywords include immunomodulation, precision medicine, nanoparticles, and oncolytic viruses.
  • Co-cited references and keyword bursts revealed a shift in focus from single-antigen CAR designs toward multifunctional, immune-enhancing strategies.

Sources:

  • "Global research trends in CAR-T cell therapy for glioblastoma: a bibliometric and visualized analysis" by Lichun Lu et al., published in Discover Oncology, 2025;16(1):1770.

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