Genetic research
New research published in the Biochemical and Biophysical Research Communications journal has demonstrated the effectiveness of a novel gene therapy in treating heart failure. The study, conducted by a team of researchers from the Veterans Affairs Medical Center in New York, successfully restored ejection fraction (EF) in mice with heart
Genetic research
Research from George Washington University has demonstrated for the first time that activating hypothalamic oxytocin neurons can improve prediabetic cardiomyopathy in a rat model. The study, published in the Journal of Physiology-London, found that stimulating these neurons through chemogenetic activation led to improved cardiac diastolic function, reduced left ventricular fibrosis,
Genes
A team of researchers at the Affiliated Hospital of Nantong University in Nantong, People's Republic of China, has designed a multifunctional poly(amidoamine) dendrimer-based gene delivery system to target activated hepatic stellate cells (aHSCs) and mitigate liver fibrosis. This innovative platform leverages clusterin (CLU) for Kupffer cell evasion,
Genes
Thanks to groundbreaking in-utero blood transfusion technology, children born with the severe, inherited blood disorder alpha thalassemia are surviving, but require lifelong specialized care. A UCLA research team led by gene therapy pioneer Dr. Donald Kohn is developing a one-time stem cell gene therapy treatment that's potentially curative.
Genes
Researchers from the Fred Hutchinson Cancer Research Center have made significant strides in gene therapy, developing a novel mobilization regimen for hematopoietic stem cells (HSCs) that has shown remarkable efficiency and reliability in nonhuman primates. The study, published in Molecular Therapy: Methods & Clinical Development, highlights the potential of this
Genes
Research published in Frontiers in Immunology has revealed a promising breakthrough in gene therapy, highlighting the potential of antigen-specific cytotoxic T lymphocyte (ACTL) therapy in overcoming resistance to chemotherapy and targeted therapy in advanced lung cancer patients. The study, led by researchers from the First Affiliated Hospital of Nanjing Medical
Genetic research
Researchers at Takeda Pharmaceutical Co. Ltd. have made significant progress in gene therapy by developing a novel positron emission tomography (PET) radiotracer that can monitor therapeutic gene expression in vivo. According to a study published in Molecular Therapy, the new radiotracer, [F]AGAL, has shown promising results in targeting the
Genetic research
Researchers from Guangzhou Medical University have discovered that a-to-I edited SNHG3 promotes non-small cell lung cancer (NSCLC) metastasis by enhancing fatty acid oxidation and resisting ferroptosis. The study, published in Communications Biology, found that the edited SNHG3 exhibits significantly greater pro-metastatic activity compared to its wild-type counterpart, triggering SSRP1-mediated replication
Genetic research
Researchers at the University of California, Los Angeles, have made significant progress in developing a gene therapy for X-linked agammaglobulinemia (XLA), a rare inborn error of immunity. According to a new study, published in Molecular Therapy: Methods & Clinical Development, the therapy has shown promising results in treating XLA patients
Genetic research
Researchers at Hangzhou Medical College have made a significant discovery in cancer gene therapy, citing the potential of Newcastle disease virus (NDV) in treating neurological tumors. According to the study, NDV can activate an anti-tumor immune response and induce apoptosis in tumor cells, making it a promising tool in cancer
Genetic research
Research conducted at King's College London has made significant strides in the field of cancer gene therapy, particularly in treating brain tumors. Investigators have developed a novel liposomal doxorubicin formulation, Talidox, designed to overcome the blood-brain barrier and deliver drugs directly to the brain. By combining Talidox with
Genetic research
A new study on gene therapy has highlighted the association between COVID-19 vaccination and thromboembolic events, particularly with adenoviral vector-based vaccines. Researchers from the Department of Cardiology underscored the rare occurrence of venous thromboembolism, arterial thromboembolism, and vaccine-induced thrombotic thrombocytopenia following COVID-19 vaccination. However, the overwhelming majority of evidence supports
