Newcastle Disease Virus Shows Promise in Cancer Gene Therapy

Researchers at Hangzhou Medical College have made a significant discovery in cancer gene therapy, citing the potential of Newcastle disease virus (NDV) in treating neurological tumors. According to the study, NDV can activate an anti-tumor immune response and induce apoptosis in tumor cells, making it a promising tool in cancer treatment. The virus has been shown to transform the immune-desert and microenvironment of tumors into immunoinflammatory tumors, activating both innate and adaptive anti-tumor immune responses.

Key Takeaways:

• Newcastle disease virus (NDV) has been found to activate an anti-tumor immune response and induce apoptosis in tumor cells.
• NDV can transform the immune-desert and microenvironment of tumors into immunoinflammatory tumors, activating innate and adaptive anti-tumor immune responses.
• The virus has been shown to have tumour-lysing properties and can induce apoptosis in tumor cells.
• The clinical application of NDV in cancer therapy is one of the emerging cancer therapies focused on by researchers with good prospects for translational applications.
• NDV uses cancer signaling pathways to transform the immune-desert and microenvironment and immune-rejecting tumors into immunoinflammatory tumors.
• The study suggests that NDV may contribute to enhancing further intervention and treatment of neurological tumors with NDV and lay the foundation for the widespread clinical use of NDV as a neoadjuvant therapeutic treatment.

Statistics:

• The study reported that NDV has the unique advantage of tumour-specific inflammation activation and drug resistance avoidance.
• The virus has been shown to induce apoptosis in tumor cells through cancer signaling pathways.
• The study concluded that NDV may contribute to enhancing further intervention and treatment of neurological tumors with NDV.
• The publisher of the journal Biochimica et Biophysica Acta can be contacted at: Elsevier, Radarweg 29, 1043 Nx Amsterdam, Netherlands.

Sources:

• Biochimica et Biophysica Acta, 2025;1871(8):168025
• NewsRx. Researchers at Hangzhou Medical College Report Findings in Cancer Gene Therapy (Prospect of Newcastle disease virus in clinical neurological tumour diseases). Cancer Weekly. September 16, 2025; p 132.