Cancer research
Researchers in Liupanshui, People's Republic of China, have made significant discoveries regarding the link between lactamase-b (LACTB) and apoptosis in gastric cancer cells. The study aimed to explore whether LACTB influences apoptosis by modulating mitochondrial autophagy through the PTEN-induced putative kinase 1 (PINK1) or Parkin pathway. The findings
Cancer research
Researchers from Shandong Provincial Hospital and Shandong First Med Univ have made a groundbreaking discovery in the field of gastric cancer treatment. By leveraging nanoparticle-based immunotherapy, they have successfully targeted the CXCL12-CXCR4 signaling pathway, reprogramming tumor-associated macrophages to enhance anti-tumor immunity. This novel approach has shown significant promise in suppressing
Cancer
Shanghai Henlius Biotech, a leading biopharmaceutical company, has announced the initiation of a phase 3 clinical trial for the treatment of gastroesophageal junction and gastric cancer in the United States. The trial, which is also ongoing in mainland China, Australia, Japan, and other countries, aims to evaluate the efficacy and
Cancer research
New research from the Pontificia Universidad Catolica de Chile has shed light on the role of galectin-9 and Tim-3 in gastric cancer. Investigators found that both galectin-9 and Tim-3 are upregulated in gastric tumors and associated with poor patient survival. Galectin-9 was found to promote Treg suppressive activity and CD8
Cancer research
Researchers at the Catholic University of Korea have developed a nomogram that can predict lymph node metastasis in stage T1b gastric cancer patients. The study, led by Ji Won Seo, utilized data from the Korean Gastric Cancer Association Survey (KGCAS) database and included 3468 patients with T1b gastric cancer. The
Cancer
Researchers from the Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University have made a significant breakthrough in treating gastric cancer. The team, led by Xiaoyan Mao, discovered that a novel nanoparticle platform targeting the SLC6A14 (ATB) transporter can effectively inhibit gastric cancer cell proliferation in
Cancer
Researchers from Kyungpook National University have developed a machine learning (ML)-based framework using clinical laboratory parameters to identify eligible participants for gastric cancer clinical trials. The framework, which was tested using electronic medical records from 11,592 patients with gastric cancer, achieved a high accuracy rate, reducing the workload
Cancer research
Researchers at Yonsei University College of Medicine have successfully performed a rare and complex surgery to treat gastric cancer accompanied by a splenic mass. The procedure, which combines splenectomy and robotic subtotal gastrectomy, has yielded promising results, allowing for the safe resection of tumors while preserving digestive functions and quality
Cancer
Researchers from the University of Leipzig have made a groundbreaking discovery in the field of personalized medicine, developing a new method to assess individualized susceptibility to chemotherapy and immune checkpoint inhibitors in gastric cancer patients. By using pretherapeutic endoscopic tissue cultures (ePDTCs), the team has demonstrated the feasibility of this
Cancer
Research published in the journal Pharmacological Research - Modern Chinese Medicine has shed light on the potential therapeutic effects of Thuja occidentalis in gastric cancer cells. The study, conducted by researchers at Mother Teresa Women's University, employed genome-wide expression profiling and evaluated the impact of Thuja on the
Cancer
Research from a team of investigators at the Jian Yang Hospital of Traditional Chinese Medicine in Chengdu, Sichuan, has provided new insights into the progression and treatment of gastric cancer. According to the study, tumor-associated macrophages (TAMs) play a crucial role in the tumor immune microenvironment, and targeting these cells
Cancer
A recent review of data on gastric cancer in Western populations has highlighted the limited cost-effectiveness of endoscopic screening and surveillance in detecting the disease. The study, conducted by researchers at Erasmus University Medical Center, found that while screening can reduce mortality rates, its cost-effectiveness in Western populations is unclear.
