T cells
Scientists at St. Jude Children's Research Hospital have made a groundbreaking discovery in understanding the metabolic control of regulatory T cells, the immune cells that prevent inappropriate immune system activation. The researchers found that mitochondria, the powerhouse of cells, and lysosomes, cellular recycling systems, work together to activate
Scientists
Researchers at Peking University have made a groundbreaking discovery in the field of immunology, identifying a naturally occurring regulatory precursor population in CD8+ T cells. This finding has significant implications for our understanding of immune homeostasis and the development of therapies for autoimmune diseases. The study, published in Science Advances,
T cells
Fresh data on proteomics have been presented in a new report from Xiamen University, shedding light on the mechanisms of T-cell differentiation and memory formation. The research, funded by several prominent Chinese science organizations, reveals that activation of the p38 MAPK pathway during the primary response of CD8+ T cells
T cells
Research conducted at Gyeongsang National University in South Korea has shed light on the optimal priming conditions for canine mesenchymal stem cells (cAMSCs), which have been widely studied for their immunomodulatory abilities in treating immune-mediated diseases. The study, funded by the National Research Foundation (NRF) of Korea, aimed to investigate
T cells
New research by a team of scientists from the University of Wisconsin Madison has made significant strides in predicting T cell receptor (TCR) activation. The study, which has been peer-reviewed, is based on a comprehensive database of 22,000 TCR-peptide pairs, centered around 25 immunogenic human and mouse epitopes, across
T cells
Researchers at Weill Cornell Medicine have found that engineered T cells have shown promise in cancer treatment, but may also recognize off-target epitopes, causing severe toxicities. The study, published in the journal Molecular Therapy, suggests that a genetic screen of 3,000 proteomic epitopes in the MHC-I ligandome uncovered off-target
T cells
Research from the Second Hospital of Hebei Medical University in Shijiazhuang, People's Republic of China, has revealed the effects of bee venom on exosomal miRNA profile in human Jurkat T cells. The study, led by Cui Ziyan and colleagues, found that bee venom treatment significantly promoted exosome release
T cells
Researchers at Guy's and St Thomas' NHS Foundation Trust and King's College London have explored the clinical potential of CAR T-cell-derived extracellular vesicles (CAR-EVs) as a revolutionary cancer treatment. CAR-EVs are nanovesicles released by CAR T cells, which can play a crucial role in intercellular
T cells
A team of researchers at the University of Veterinary and Animal Sciences in Lahore, Pakistan, has developed a gamma-irradiated Salmonella Gallinarum (g-SG) oral vaccine that elicits robust cellular and humoral immune responses in chickens. The study aimed to evaluate the efficacy of this vaccine in a chicken model, focusing on
T cells
Researchers at Mayo Clinic Arizona have made significant progress in addressing the limitations of chimeric antigen receptor (CAR) T cell therapy in treating solid tumors. The study, published in Frontiers in Immunology, introduces a new class of engineered receptors that modulate T cell activity independently of direct antigen recognition. Chimeric
T cells
New research by a team of scientists from the University of Wisconsin Madison has made significant strides in predicting T cell receptor (TCR) activation. The study, which has been peer-reviewed, is based on a comprehensive database of 22,000 TCR-peptide pairs, centered around 25 immunogenic human and mouse epitopes, across
T cells
Fresh data on Proteins - Transcription Factors have been presented in a new report from the Sloan Kettering Institute, detailing the role of Foxp3 in regulatory T cells. According to the researchers, Foxp3 is essential for the establishment of transcriptional and functional programs in newly generated T cells, but its
