Dietary Inflammatory Indices Linked to Increased Mortality Risk in Patients with Cirrhosis

A cohort study published in the journal Scientific Reports has investigated the association between dietary inflammatory indices and total mortality in patients with cirrhosis. The research, conducted by a team of researchers from Shahid Beheshti University of Medical Sciences, analyzed the dietary intake of 166 outpatients with cirrhosis and found a significant association between dietary inflammatory indices and increased mortality risk.

Key Takeaways:

• The study found that dietary inflammatory indices, including the dietary inflammatory index (DII), empirical dietary inflammatory pattern (EDIP), and dietary inflammatory score (DIS), were significantly associated with increased mortality risk in patients with cirrhosis.
• After full adjustment for confounders, the results showed that mortality risk increased significantly with increasing dietary inflammatory indices.
• Compared to the first tertile, the risk of mortality due to cirrhosis was associated with 4.8 times increase in the third tertile of DII, 3.3 times in the third tertile of EDIP, and 2.2 times increased in the third tertile of DIS.
• The study concluded that the results indicated a significant association between dietary inflammatory indices and total mortality among patients with cirrhosis, highlighting the importance of dietary factors in the development and progression of cirrhosis.
• The study's findings emphasize the need for additional research to confirm the results and to investigate the potential mechanisms by which dietary inflammatory indices influence cirrhosis mortality.

Statistics:

• The study analyzed the dietary intake of 166 outpatients with cirrhosis over a period of 48 months.
• The researchers used a 168-question valid food frequency questionnaire to evaluate dietary intake.
• The dietary inflammatory index (DII) was calculated for each participant, with a range of 0-164.3.
• The empirical dietary inflammatory pattern (EDIP) and dietary inflammatory score (DIS) were also calculated for each participant.
• The study found significant associations between dietary inflammatory indices and increased mortality risk, with a 4.8 times increase in mortality risk in the third tertile of DII, a 3.3 times increase in the third tertile of EDIP, and a 2.2 times increase in the third tertile of DIS.

Sources:

• Khodadadi, N., et al. (2024). The association of dietary inflammatory indices and mortality in patients with cirrhosis: a cohort based study. Scientific Reports, 14(1), 1-8. (doi: 10.1038/s41598-024-72485-x)
• Available at: https://doi-org.sdpl.idm.oclc.org/10.1038/s41598-024-72485-x