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Edema

Researchers Discover New Treatment for Macular Edema Using Bromelain and Diosmin

Strategic Insights

— 2 min read

Researchers from Sapienza University of Rome have found that an oral formulation combining bromelain and diosmin has a positive impact on central retinal thickness in patients with diabetic macular edema. This study aimed to assess the effects of this combination on visual acuity and central retinal thickness in patients undergoing anti-VEGF intravitreal maintenance therapy. The researchers prospectively enrolled 40 patients with type 2 diabetes and center-involving diabetic macular edema and divided them into two groups: one receiving the oral supplement and the other not receiving it. The results showed a statistically significant improvement in central retinal thickness in the group receiving the supplement.

Key Takeaways:

  • The study examined the effects of an oral formulation combining bromelain and diosmin on visual acuity and central retinal thickness in patients with diabetic macular edema.
  • The treatment group consisted of 20 eyes receiving the supplement, while the control group consisted of 20 eyes without the supplement.
  • The supplement resulted in a statistically significant improvement in central retinal thickness compared to the control group after two months.
  • The researchers observed that the combination of bromelain and diosmin had a positive impact on central retinal thickness in patients treated for cystoid center-involving diabetic macular edema with anti-VEGF intravitreal maintenance therapy.
  • The study provides new evidence for the treatment of diabetic macular edema using oral formulations of bromelain and diosmin.
  • The results of this study can contribute to further research on the use of natural compounds in the treatment of eye diseases.
  • The researchers suggest that the combination of bromelain and diosmin may be a useful adjunct therapy for patients undergoing anti-VEGF intravitreal maintenance therapy.

Statistics:

  • The study consisted of 40 patients with type 2 diabetes and center-involving diabetic macular edema, divided into two groups of 20 eyes each.
  • The treatment group received the oral supplement of bromelain and diosmin, while the control group did not receive the supplement.
  • After two months, the treatment group showed a statistically significant improvement in central retinal thickness compared to the control group.
  • The study concluded that the orally administered combination of bromelain 250 mg and 250 mg diosmin mcgSMIN Plus resulted in a positive impact on central retinal thickness in patients treated for cystoid center-involving diabetic macular edema with anti-VEGF intravitreal maintenance therapy.

Sources:

  • Diabetic Macular Edema in Maintenance Intravitreal Scheduling. Pharmaceutics, 2025,17(5):605. (Pharmaceutics - http://www.mdpi.com/journal/pharmaceutics/). The publisher for Pharmaceutics is MDPI AG.
  • NewsRx. Reports from Sapienza University of Rome Describe Recent Advances in Macular Edema (Diabetic Macular Edema in Maintenance Intravitreal Scheduling). Health & Medicine Week. June 13, 2025; p 269.

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