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Dietary Nutrient Intake Linked to Reduced Coronary Heart Disease Risk in Older Adults

Strategic Insights

— 1 min read

A study published in Frontiers in Nutrition has investigated the relationship between dietary nutrient intake and coronary heart disease (CHD) risk among older adults with accelerated aging. The research analyzed data from seven cycles of the National Health and Nutrition Examination Survey (NHANES) conducted in the United States between 2005 and 2018. The study found that dietary nutrient mixtures were inversely associated with CHD risk in older adults experiencing accelerated aging, with both SHAP and LIME analyses identifying vitamin B12 and lutein + zeaxanthin as protective nutrients.

Key Takeaways:

  • The study analyzed data from seven cycles of the National Health and Nutrition Examination Survey (NHANES) conducted between 2005 and 2018.
  • The research found that dietary nutrient mixtures were inversely associated with CHD risk in older adults experiencing accelerated aging (adjusted OR = 0.90, 95% CI: 0.81-0.99, = 0.048).
  • Vitamin B12 and lutein + zeaxanthin were identified as protective nutrients, independent of demographic adjustments, through both SHAP and LIME analyses.
  • The random forest algorithm demonstrated the strongest predictive performance among the machine learning models tested.
  • The study highlights the importance of specific dietary nutrients in reducing CHD risk among adults aged 50 and older with accelerated aging.

Statistics:

  • 45 dietary nutrients were analyzed in the study.
  • The adjusted OR for the inverse association between dietary nutrient mixtures and CHD risk was 0.90 (95% CI: 0.81-0.99, = 0.048).
  • The study included data from 7 cycles of the NHANES conducted between 2005 and 2018.

Sources:

  • Interpretable prediction of coronary heart disease risk in adults over 50 with accelerated aging using 45 dietary nutrients. Frontiers in Nutrition, 2025;12:1666644.
  • NewsRx. Studies from Third Affiliated Hospital Add New Findings in the Area of Heart Disease (Interpretable prediction of coronary heart disease risk in adults over 50 with accelerated aging using 45 dietary nutrients). Cardiovascular Week. October 20, 2025; p 170.

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