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HIV patients

Extensive Condyloma Lata Lesions in Unusual Sites: A Rare Manifestation of Secondary Syphilis

Strategic Insights

— 1 min read

A new study has highlighted the importance of awareness among healthcare professionals about the atypical manifestations of secondary syphilis, particularly in patients with human immunodeficiency virus (HIV) infection. According to a report published in Case Reports in Medicine, a 46-year-old man with HIV Stage II presented with extensive condyloma lata lesions in unusual sites, such as the face, trunk, and anogenital area. The lesions were diagnosed through histopathological and serological evaluation, and the patient was treated with a single dose of benzylpenicillin G.

Key Takeaways:

  • The study highlights the importance of awareness among healthcare professionals about the atypical manifestations of secondary syphilis, particularly in patients with HIV infection.
  • The patient presented with extensive condyloma lata lesions in unusual sites, including the face, trunk, and anogenital area.
  • The lesions were diagnosed through histopathological and serological evaluation, including a Treponema pallidum hemagglutination assay and Venereal Disease Research Laboratory (VDRL) titer.
  • The patient was treated with a single dose of 2.4 million units of benzylpenicillin G intramuscularly, resulting in improvement of the skin lesions.
  • The study emphasizes the need for early diagnosis and treatment of secondary syphilis to prevent complications.
  • The patient's HIV status and CD4+ T cell count were not available for this patient.

Statistics:

  • 1:5120 - The Treponema pallidum hemagglutination assay titer of the patient.
  • 1:256 - The Venereal Disease Research Laboratory (VDRL) titer of the patient.
  • 2.4 million units - The dose of benzylpenicillin G administered intramuscularly.
  • 3 months - The duration of therapy post-treatment.
  • 1:32 - The VDRL titer examination result after 3 months of therapy.

Sources:

  • Extensive Condyloma Lata Lesions in Unusual Sites: An Atypical Manifestation of Secondary Syphilis. Case Reports in Medicine, 2025,2025. (https://www.hindawi.com/journals/crim/)
  • NewsRx. Study Results from Department of Dermatology and Venereology Provide New Insights into HIV/AIDS (Extensive Condyloma Lata Lesions in Unusual Sites: An Atypical Manifestation of Secondary Syphilis). AIDS Weekly. October 20, 2025; p 240.

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