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Cancer research

External Validation of Venous Thromboembolism Risk Assessment Models After Colorectal Cancer Surgery

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— 1 min read

Researchers at Capital Medical University conducted a retrospective study to evaluate the external validity of four venous thromboembolism (VTE) risk assessment models in Chinese patients undergoing colorectal cancer surgery. The study analyzed demographic characteristics, clinical data, and postoperative VTE status of 323 patients from January 2020 to December 2023. The researchers estimated the VTE predictive performance of the four models using area under the receiver operating characteristic curve (AUROC), calibration plots, Hosmer-Lemeshow test, and decision curve analysis.

Key Takeaways:

  • The study included 323 patients, with a median age of 66 years and 56.3% male participants.
  • VTE occurred in 68 (21.1%) cases within 6 months after operation, with 5 cases of pulmonary embolism and 63 cases of deep vein thrombosis.
  • The Sir-Run-Run-Shaw VTE RAM, RVTA score, CRC-VTE score, and Caprini score demonstrated possible discrimination in predicting VTE risk, with AUROC values of 0.691, 0.638, 0.728, and 0.661, respectively.
  • The Hosmer-Lemeshow test indicated a lack of fit for Sir-Run-Run-Shaw VTE RAM, RVTA score, and CRC-VTE score (P<0.05).
  • The researchers concluded that the study can help clinicians identify patients with high risk of VTE, facilitating timely prophylactic interventions and close monitoring.

Statistics:

  • Total number of patients: 323
  • Male participants: 182 (56.3%)
  • Median age: 66 years
  • VTE incidence: 68 (21.1%)
  • Pulmonary embolism cases: 5
  • Deep vein thrombosis cases: 63
  • Events within 4 weeks after operation: 45 (66.2%)
  • AUROC values for the four VTE RAMs: 0.691, 0.638, 0.728, and 0.661

Sources:

  • External validation of four venous thromboembolism risk assessment models after colorectal cancer surgery: a retrospective study. Thrombosis Journal, 2025;23(1):92.
  • Bmc, Campus, 4 Crinan St, London N1 9XW, England. (BioMed Central - www.biomedcentral.com/; Thrombosis Journal - www.thrombosisjournal.com)
  • Ying Zhao, Dept. of Pharmacy, Beijing Friendship Hospital, Capital Medical University, Beijing, People's Republic of China.

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