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Asian medicine

Kuntai Capsule Shows Promise in Treating Menopausal Symptoms Induced by GnRH-a Therapy

Strategic Insights

— 1 min read

New research from the Beijing University of Chinese Medicine has found that the Kuntai capsule can significantly reduce menopausal symptoms in women undergoing Gonadotropin-releasing hormone agonist (GnRH-a) therapy. The study, published in the Journal of Ethnopharmacology, analyzed data from 36 randomized controlled trials involving 3,577 patients.

Kuntai capsule, a traditional Chinese medicine, is often used to alleviate various menopausal symptoms. However, its effectiveness in treating menopausal symptoms induced by GnRH-a therapy has not been extensively studied. The current study aimed to evaluate the efficacy and safety of Kuntai capsule in this specific context.

**Key Takeaways:**

  • The study included 36 randomized controlled trials with a total of 3,577 patients.
  • Kuntai capsule combined with GnRH-a significantly reduced the Kupperman Index (KI) compared to GnRH-a alone (MD = -5.88, 95% CI [-9.80, -1.96], P = 0.003).
  • The incidence of hot flashes was also significantly reduced with Kuntai capsule combined with GnRH-a (RR = 0.49, 95% CI [0.36, 0.68], P < 0.001).
  • The study found no significant difference in adverse events between the two groups.
  • The researchers noted that the methodological limitations of the included RCTs require further high-quality evidence from large-sample and well-designed research.

**Statistics:**

  • 36 randomized controlled trials were included in the meta-analysis.
  • 3,577 patients were involved in the study.
  • The Kupperman Index (KI) was significantly reduced with Kuntai capsule combined with GnRH-a (MD = -5.88, 95% CI [-9.80, -1.96], P = 0.003).
  • The incidence of hot flashes was significantly reduced with Kuntai capsule combined with GnRH-a (RR = 0.49, 95% CI [0.36, 0.68], P < 0.001).

**Sources:**

  • Kuntai Capsule for the Treatment of Menopausal Symptoms Induced by GnRH-a Therapy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials (Journal of Ethnopharmacology, 2025:120685).
  • Beijing University of Chinese Medicine (Beijing, People's Republic of China).
  • Elsevier Ireland Ltd, Elsevier House, Brookvale Plaza, East Park Shannon, Co, Clare, 00000, Ireland (Elsevier - www.elsevier.com; Journal of Ethnopharmacology - www.journals.elsevier.com/journal-of-ethnopharmacology/).

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