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Adult respiratory distress syndrome

Mechanical Power in Acute Lung Injury: A Correlation Study

Strategic Insights

— 1 min read

Researchers from Mahidol University in Thailand have investigated the correlation between mechanical power and clinical outcomes in mechanically ventilated patients. The study, published in BMJ Open Respiratory Research, aimed to determine mechanical power in patients admitted to the surgical intensive care unit (SICU) who required mechanical ventilation (MV) support. The research found a significant association between mechanical power and 90-day mortality, particularly in cases with high illness acuity.

Key Takeaways:

  • The study included 283 postoperative patients admitted to the SICU who required MV support for 12 hours.
  • Mechanical power (MP) at MV initiation and 24 hours were median 11.9 (IQR 8.6-17.1) J/min and 11.9 (8.9-16.8) J/min, respectively.
  • MP was significantly higher in non-survivors both at MV initiation and 24 hours (15.4 (12.5-21.2) J/min vs 11 (8.3-15.6) J/min, p < 0.01).
  • The research concluded that mechanical power was an independent predictor of elevated 90-day mortality, especially in cases with high illness acuity.
  • Alterations in mechanical power during MV support could impact 90-day mortality in these individuals.
  • The study was funded by the Siriraj Research And Development Fund, Faculty of Medicine, Siriraj Hospital, Mahidol University, Thailand.

Statistics:

  • 283 patients were included in the retrospective cohort study.
  • Mechanical power at MV initiation was median 11.9 (IQR 8.6-17.1) J/min.
  • Mechanical power at 24 hours was median 11.9 (8.9-16.8) J/min.
  • 90-day mortality was reportedly higher in non-survivors with elevated mechanical power.

Sources:

  • "Mechanical power in patients receiving mechanical ventilation in the surgical intensive care unit and its association with increased mortality: a retrospective cohort study." BMJ Open Respiratory Research, 2025, 12(1). (BMJ Open Respiratory Research - http://bmjopenrespres.bmj.com/)
  • NewsRx. Researchers from Mahidol University Provide Details of New Studies and Findings in the Area of Acute Lung Injury (Mechanical power in patients receiving mechanical ventilation in the surgical intensive care unit and its association with ...). Respiratory Therapeutics Week. October 20, 2025; p 1876.

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