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Adult respiratory distress syndrome

Zerumbone Attenuates Acute Lung Injury in Mice by Suppressing NLRP3/Caspase-1/GSDMD Signalling Pathway

Strategic Insights

— 1 min read

Researchers at the College of Medicine, Shaoxing Vocational & Technology College, have discovered that zerumbone, a cyclic sesquiterpene compound, can attenuate acute lung injury in mice by suppressing the NLRP3/Caspase-1/GSDMD signalling pathway. This finding highlights the potential of zerumbone as a novel therapeutic agent for the treatment of acute lung injury.

Key Takeaways:

  • Zerumbone, a compound found in the wild ginger species Zingiber zerumbet, exhibits anti-inflammatory and antioxidant properties.
  • In a murine lipopolysaccharide-induced acute lung injury model, zerumbone treatment reduced lung tissue injury, inflammation, and oxidative stress.
  • Zerumbone counteracted pyroptosis in the alveolar epithelial cells of mice, mitigating acute lung injury progression.
  • In MLE-12 cells, zerumbone significantly inhibited oxidative stress and inflammation, suppressing NLRP3/Caspase-1/GSDMD signalling.
  • Zerumbone may serve as a potential novel therapeutic agent for acute lung injury.

Statistics:

  • 11 carbon atoms: The number of carbon atoms in the cyclic sesquiterpene compound zerumbone.
  • 10 mM: The concentration of zerumbone used in the pretreatment of mouse alveolar epithelial (MLE)-12 cells.
  • 1 ng/mL: The concentration of lipopolysaccharide (LPS) used in the incubation of MLE-12 cells.
  • 24 h: The duration of the incubation period for MLE-12 cells.
  • 29(19): The issue number of the Journal of Cellular and Molecular Medicine, where the research was published.

Sources:

  • NewsRx. New Acute Lung Injury Findings Has Been Reported by Researchers at College of Medicine (Zerumbone Attenuates Lipopolysaccharide-Induced Acute Lung Injury by Suppressing the NLRP3/Caspase-1/GSDMD Signalling Pathway). Respiratory Therapeutics Week. October 20, 2025; p 2146.
  • Zerumbone Attenuates Lipopolysaccharide-Induced Acute Lung Injury by Suppressing the NLRP3/Caspase-1/GSDMD Signalling Pathway. Journal of Cellular and Molecular Medicine, 2025;29(19).
  • Wiley, 111 River St, Hoboken 07030-5774, NJ, USA (Publisher of the Journal of Cellular and Molecular Medicine)
  • Fei-Fei Fang, College of Medicine, Shaoxing Vocational & Technology College, Shaoxing, People's Republic of China (Corresponding author)

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