Sign in Subscribe
Asthma

Asthma Remission: New Research Reveals Significant Unmet Need

Strategic Insights

— 2 min read

New research published in the World Allergy Organization Journal has shed light on the predictors and achievability of long-term asthma remission. The study, conducted by researchers from the Airway Research Center North, included 203 adults with mild to severe asthma, who were followed over a period of 6 years. The findings revealed that only 27% of participants achieved long-term remission, with 34% achieving short-term remission, and 39% never achieving remission.

Key Takeaways:

  • The study identified predictors of no asthma remission, including number of persistent T2-markers, frequency dependence of resistance, FEV1/FVC, GERD, CVD, dyslipidemia, while sensitization to house dust mite was associated with a higher remission rate.
  • The researchers found that during long-term follow-up, significant adjusted predictors of no remission were sputum eosinophils, small airway dysfunction, and airflow obstruction.
  • The study highlighted a substantial unmet need in achieving long-term remission, particularly in patients with persistent type 2 inflammation and impaired lung function.
  • The research team emphasized the importance of targeting T2 inflammation earlier to prevent lung function impairment.
  • The study included a cohort of 203 adults with mild to severe asthma, followed over 6 years, with 5 visits to assess type 2 inflammation markers, lung function measurements, and systemic comorbidities.
  • Clinical remission was defined by an Asthma Control Test score of 20 plus the absence of both severe exacerbations and systemic corticosteroid use in the past 12 months, and normal or stable lung function.

Statistics:

  • 27% of participants achieved long-term remission
  • 34% of participants achieved short-term remission
  • 39% of participants never achieved remission and had persistent T2 markers despite high-dose ICS
  • 16% of patients with severe asthma achieved long-term remission, compared to 65% of those with mild-to-moderate disease
  • 1/3 of all patients never achieved remission
  • Number of persistent T2-markers had an OR of 0.26 (CI: 0.11, 0.61) for no asthma remission
  • Frequency dependence of resistance had an OR of 0.36 (CI: 0.15, 0.82) for no asthma remission
  • FEV1/FVC had an OR of 0.16 (CI: 0.06, 0.37) for no asthma remission
  • GERD had an OR of 0.23 (CI: 0.1, 0.5) for no asthma remission
  • CVD had an OR of 0.44 (CI: 0.22, 0.87) for no asthma remission
  • Dyslipidemia had an OR of 0.38 (CI: 0.13, 1.05) for no asthma remission
  • Sensitization to house dust mite had an OR of 2.06 (CI: 1.03, 4.17) for higher remission rate

Sources:

  • Exploring trends and predictors of long-term asthma remission. World Allergy Organization Journal, 2025,18(10):101127. (World Allergy Organization Journal - https://www.journals.elsevier.com/world-allergy-organization-journal/). The publisher for World Allergy Organization Journal is Elsevier.
  • A free version of this journal article is available at https://doi-org.sdpl.idm.oclc.org/10.1016/j.waojou.2025.101127.

Read more