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Cancer research

Prostatic Inflammation Score Predicts Biochemical Recurrence after Radical Prostatectomy

Strategic Insights

— 2 min read

A study published in the World Journal of Urology has found that the prostatic inflammation score (PIS) can predict the risk of biochemical recurrence (BCR) after radical prostatectomy (RP). The study, conducted by researchers at the University of Foggia in Italy, evaluated the relationship between PIS and BCR in 679 patients who underwent RP between 2013 and 2023.

The PIS was assessed by integrating the Irani Grade (G) and Aggressiveness (A) on hematoxylin and eosin-stained biopsy cores. The patients were categorized into three groups based on PIS: PIS 1 (G 0-1/A 0-1), PIS 2 (G 2-3/A 0-1), and PIS 3 (G 0-3/A 2-3). The study found that the incidence of BCR at six years was highest in PIS 1 (30%) compared to PIS 2 (10%) and PIS 3 (9%) (p = 0.002).

Key Takeaways:

  • The prostatic inflammation score (PIS) is a novel tool that integrates Irani Grade (G) and Aggressiveness (A) to predict the risk of biochemical recurrence (BCR) after radical prostatectomy (RP).
  • A total of 679 patients were included in the study, with a median follow-up of 36 months.
  • The incidence of BCR was highest in PIS 1 (30%) compared to PIS 2 (10%) and PIS 3 (9%) (p = 0.002).
  • The hazard ratios (HR) for BCR were 0.44 (95% CI: 0.27-0.74) for PIS 2 and 0.37 (95% CI: 0.15-0.91) for PIS 3 compared to PIS 1.
  • The study found an inverse correlation between IRANI G scores and BCR risk, while IRANI A scores (2-3) showed a nonsignificant trend.
  • Gleason grade and pT stage were significantly associated with BCR, while margin status and pN stage were not.

Statistics:

  • 127 patients (18.7%) experienced BCR during the median follow-up of 36 months.
  • The incidence of BCR at six years was highest in PIS 1 (30%) compared to PIS 2 (10%) and PIS 3 (9%) (p = 0.002).
  • The hazard ratios (HR) for BCR were 0.44 (95% CI: 0.27-0.74) for PIS 2 and 0.37 (95% CI: 0.15-0.91) for PIS 3 compared to PIS 1.

Sources:

  • NewsRx. New Prostatectomy Study Findings Reported from University of Foggia (The prostatic inflammation score and risk of biochemical recurrence following radical prostatectomy). Health & Medicine Week. October 24, 2025; p 1170.
  • The prostatic inflammation score and risk of biochemical recurrence following radical prostatectomy. World Journal of Urology, 2025;43(1):601.

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