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COVID-19

COVID-19 Mortality Factors Identified in Brazilian Study

Strategic Insights

— 1 min read

Research conducted by Universidade Federal de Uberlandia has unveiled significant factors contributing to mortality among patients with severe acute respiratory syndrome (SARS) due to COVID-19. The study, published in Revista de Epidemiologia e Controle de Infeccao, explored the association between sociodemographic, clinical, and hospitalization variables and mortality rates among hospitalized patients. The findings suggest that age, pre-existing clinical conditions, and intensive care unit (ICU) hospitalization significantly impact mortality rates.

Key Takeaways:

  • The study evaluated 592 COVID-19 notifications from April 4th to October 2nd, 2021, in Ituiutaba-MG, Brazil, out of 8,770 confirmed cases.
  • Fewer years of education, vaccination with two doses, and need for invasive ventilation were associated with mortality.
  • The risk of death increased with every year of life, with a prevalence ratio (PR) of 1.03 (95% confidence interval [CI] 1.02-1.04).
  • The presence of chronic disease (PR=1.55; 95% CI 1.1-2.18) and ICU hospitalization (PR= 3.49; 95% CI 2.7-4.54) also contributed to mortality.
  • The study concluded that, in addition to age, pre-existing clinical conditions, and ICU hospitalization, contribute to mortality.
  • The research was conducted by Victor Antonio Ferreira Freire, Universidade Federal de Uberlandia, and other authors, including Gustavo Siconello dos Santos, Morun Bernardino Neto, Luciana Karen Calabria, and Alexandre Azenha Alves de Rezende.

Statistics:

  • 592 notifications were evaluated from April 4th to October 2nd, 2021.
  • 8,770 COVID-19 cases were confirmed.
  • The mortality rate increased with every year of life (PR=1.03; 95% CI 1.02-1.04).
  • Chronic disease was associated with a 55% increased risk of mortality (PR=1.55; 95% CI 1.1-2.18).
  • ICU hospitalization was associated with a 349% increased risk of mortality (PR=3.49; 95% CI 2.7-4.54).

Sources:

  • Revista de Epidemiologia e Controle de Infeccao, 2025,15(1).
  • Universidade de Santa Cruz do Sul. (publisher).
  • https://doi-org.sdpl.idm.oclc.org/10.17058/reci.v15i1.19438 (free version of the journal article).
  • NewsRx. Reports on COVID-19 Findings from Universidade Federal de Uberlandia Provide New Insights (Association of biological factors, social determinants of health, and hospitalization with mortality due to SARS/Covid-19). Medical Letter on the CDC & FDA. October 26, 2025; p 372.

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