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Adipose tissue

Association Between Epicardial Adipose Tissue Volume and Changes in Left Ventricular Ejection Fraction in Patients With Acute Coronary Syndrome

Strategic Insights

— 2 min read

A new study published in the Journal of Atherosclerosis and Thrombosis has shed light on the relationship between epicardial adipose tissue (EAT) volume and changes in left ventricular ejection fraction (LVEF) in patients with acute coronary syndrome (ACS). The research, conducted at Chubu Rosai Hospital, evaluated the association between EAT volume and temporal LVEF changes in 197 patients hospitalized for ACS. The study found that there was no association between EAT volume at the onset of ACS and the difference in LVEF during follow-up.

Key Takeaways:

  • The study included 197 patients with ACS, with 143 undergoing follow-up echocardiography for three years.
  • Patients were divided into three groups according to their LVEF: heart failure with reduced EF (HFrEF), heart failure with mildly reduced EF (HFmrEF), and heart failure with preserved EF (HFpEF).
  • Peak creatine phosphokinase levels during ACS were most strongly correlated with the chronic-phase LVEF (r = -0.51, p < 0.01), but EAT volume was not associated with changes in LVEF.
  • Patients with chronic HFrEF had a significantly higher EAT volume despite not being obese.
  • The study was a prospective cohort study conducted at Chubu Rosai Hospital, and the results were peer-reviewed.
  • The research has significant implications for understanding the relationship between EAT and LVEF in patients with ACS.

Statistics:

  • The study included 197 patients with ACS, with 143 undergoing follow-up echocardiography for three years.
  • The patients were divided into three groups according to their LVEF: 86 males with heart failure with reduced EF (15%), 67 males with heart failure with mildly reduced EF (23%), and 90 males with heart failure with preserved EF (62%).
  • Peak creatine phosphokinase levels during ACS were most strongly correlated with the chronic-phase LVEF (r = -0.51, p < 0.01), with a correlation coefficient of -0.51 and a p-value of 0.008.
  • Patients with chronic HFrEF had a significantly higher EAT volume despite not being obese, with an EAT volume of 5.75 cm³ (95% CI 5.42-6.08, p < 0.01).

Sources:

  • Association Between Epicardial Adipose Tissue Volume and Changes In Left Ventricular Ejection Fraction In Patients With Acute Coronary Syndrome. Journal of Atherosclerosis and Thrombosis, 2025.
  • Japan Atherosclerosis Soc, Nichinai-Kaikan B1, 3-28-8 Hongo Bunkyo-Ku, Tokyo, 113-0033, Japan.
  • Ken Harada, Chubu Rosai Hospital, Dept. of Cardiology, 10-6 1 Chome Komei, Minato Ku, Nagoya 4558530, Japan.
  • NewsRx. Studies Conducted at Chubu Rosai Hospital on Acute Coronary Syndrome Recently Reported (Association Between Epicardial Adipose Tissue Volume and Changes In Left Ventricular Ejection Fraction In Patients With Acute Coronary Syndrome). Cardiovascular Week. October 27, 2025; p 152.

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