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Cardiovascular diseases

Association Between Triglyceride-Glucose Index and Peripheral Artery Disease Revealed

Strategic Insights

— 1 min read

Investigations have highlighted the potential link between the triglyceride-glucose (TyG) index, a marker of insulin resistance, and peripheral artery disease (PAD). A comprehensive meta-analysis published by researchers from the Xuanwu Hospital of Capital Medical University has shed light on this association. The study, which pooled data from 37,761 participants across nine observational studies, found a significant positive correlation between high TyG index values and the risk of PAD. Notably, the results suggest that individuals with diabetes are particularly vulnerable to this association.

Key Takeaways:

  • The TyG index, a measure of insulin resistance, is linked to an increased risk of peripheral artery disease (PAD).
  • Nine observational studies with a total of 37,761 participants were included in the meta-analysis.
  • Individuals with high TyG index values had significantly increased odds of PAD (RR: 1.42, 95% CI: 1.21-1.67, p < 0.001).
  • The association between TyG index and PAD is particularly pronounced in people with diabetes.
  • These findings suggest that the TyG index could be used as a valuable marker for assessing PAD risk in clinical practice.
  • Lei Zhao and Xiao-Lu Fei, alongside Lan Wei, are authors of the research.
  • The study was peer-reviewed and published in the journal Hormone and Metabolic Research in 2025.

Statistics:

  • 37,761 participants were involved in the meta-analysis across nine observational studies.
  • The incidence of PAD was significantly higher in individuals with high TyG index values.
  • The risk ratio (RR) for PAD was 1.42 (95% CI: 1.21-1.67, p < 0.001).
  • The study found that individuals with diabetes are particularly susceptible to PAD in the context of a high TyG index.
  • The TyG index is a valuable marker for assessing PAD risk in clinical practice.

Sources:

  • NewsRx. New Findings from Xuanwu Hospital of Capital Medical University in the Area of Peripheral Artery Disease Reported (Association Between the Triglyceride-Glucose Index and Peripheral Artery Disease: A Meta-Analysis). Hematology Week. October 27, 2025; p 276.
  • Association Between the Triglyceride-Glucose Index and Peripheral Artery Disease: A Meta-Analysis. Hormone and Metabolic Research, 2025.
  • Georg Thieme Verlag Kg, Rudigerstr 14, D-70469 Stuttgart, Germany (publisher of Hormone and Metabolic Research)

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