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Chronic kidney failure

Adverse Childhood Experiences Linked to Poor Health Outcomes in Children with Chronic Kidney Disease

Strategic Insights

— 1 min read

Research from Children's Mercy Kansas City reveals a strong association between adverse childhood experiences (ACEs) and poor health outcomes in children with chronic kidney disease (CKD). The study, which analyzed data from the Chronic Kidney Disease in Children (CKiD) study, found that children with CKD who experienced two or more ACEs had a faster progression of their disease compared to those without such experiences. The study's findings highlight the importance of addressing ACEs in pediatric CKD patients to mitigate their negative impact on health outcomes.

Key Takeaways:

  • The study found a significant association between ACEs and poor health outcomes in children with CKD, with children experiencing two or more ACEs progressing their disease faster than those without such experiences.
  • The majority of ACEs were noted at a higher prevalence in the CKiD cohort compared to the average national population.
  • The study recommends further characterization of all potential ACE exposures in children with CKD to design intervention strategies that can mitigate their harmful impact.
  • The CKiD study cohort comprised 350 children with mild to moderate CKD.
  • The study used a generalized gamma time-to-event model to compare CKD progression among CKiD participants who experienced 2 or more ACEs versus those who did not.
  • The study highlights the importance of addressing ACEs in pediatric CKD patients to improve health outcomes.
  • The researchers recommend developing interventions to mitigate the negative impact of ACEs on CKD progression in children.

Statistics:

  • The study cohort comprised 350 children with mild to moderate CKD.
  • The majority of ACEs were noted at a higher prevalence in the CKiD cohort compared to the average national population (P < 0.05).
  • 60% of the CKiD cohort experienced two or more ACEs.
  • Children with CKD who experienced two or more ACEs had a faster progression of their disease compared to those without such experiences.

Sources:

  • NewsRx. Findings from Children's Mercy Kansas City Reveals New Findings on Chronic Kidney Disease (The Association of Adverse Childhood Experiences With the Progression of Chronic Kidney Disease In Children: a Ckid Pilot Study). Pediatrics Week. November 1, 2025; p 109.
  • The Association of Adverse Childhood Experiences With the Progression of Chronic Kidney Disease In Children: a Ckid Pilot Study. Pediatric Nephrology, 2025.

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