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Coronary heart disease

Acid Reflux Disease Linked to Increased Risk of Coronary Artery Disease

Strategic Insights

— 1 min read

Research published in the journal Clinical Cardiology has found a causal link between gastroesophageal reflux disease (GERD) and coronary artery disease (CAD). The study, conducted by a team of researchers from the People's Hospital of Yangjiang, applied multivariable Mendelian randomization (MVMR) to explore the relationship between GERD and CAD using genetic instruments derived from genome-wide association studies (GWAS). The results suggest that genetically predicted GERD is causally linked with CAD, independent of metabolic risk factors.

Key Takeaways:

  • The study found a significant causal link between GERD and CAD, with a correlation coefficient of 0.38 (P = 2.37E-52) indicating a strong association between the two conditions.
  • The MVMR models adjusted for key metabolic confounders, including low-density lipoprotein cholesterol (LDL-C), body mass index (BMI), systolic blood pressure (SBP), and glycated hemoglobin (HbA1c), indicating that GERD is an independent risk factor for CAD.
  • The study identified pleiotropic genes and shared genetic loci between GERD and CAD, with IGF2BP1 emerging as a potential therapeutic target for intervention.
  • The research has significant implications for the prevention and management of CAD, highlighting the importance of addressing GERD as a potential risk factor.

Statistics:

  • A total of 0.38 (rg = 0.38) correlation coefficient was observed between GERD and CAD, indicating a strong causal link between the two conditions.
  • The P-value of 2.37E-52 indicates a highly significant association between GERD and CAD.
  • The odds ratio of 1.24 (95% CI: 1.02-1.52, p < 0.75) suggests that high levels of GERD increase the risk of CAD.

Sources:

  • NewsRx. Reports Summarize Acid Reflux Disease Findings from People's Hospital of Yangjiang (Mapping Gastroesophageal Reflux Disease and Coronary Artery Disease: A Comprehensive Analysis of Multivariable Mendelian Randomization and Shared Genetic ...). Cardiovascular Week. November 3, 2025; p 74.
  • Clinical Cardiology. Mapping Gastroesophageal Reflux Disease and Coronary Artery Disease: A Comprehensive Analysis of Multivariable Mendelian Randomization and Shared Genetic Etiology. Clinical Cardiology, 2025;48(10). Wiley, 111 River St, Hoboken 07030-5774, NJ, USA.

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