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New Insights into Seizure Disorders: Personalized Care Through Clinical Profiles

Strategic Insights

— 1 min read

Researchers from the University of Lorraine and the National Center for Scientific Research (CNRS) conducted a study to compare the demographic, psychiatric, neurological, and trauma profiles of patients with functional/dissociative seizures, epilepsy, and the co-occurrence of both conditions. The study, which analyzed 296 patients, found significant differences in the profiles of patients with functional/dissociative seizures (FDS), epilepsy, and the co-occurrence of both conditions. The findings suggest that personalized care can be offered to patients with seizure disorders by accurately differentiating clinical profiles.

Key Takeaways:

  • The study compared the demographic, psychiatric, neurological, and trauma profiles of 296 patients with functional/dissociative seizures, epilepsy, and the co-occurrence of both conditions.
  • The FDS-only group was more likely to be female (p=.004) and have a later seizure onset (p<.001).
  • Sexual trauma and late seizure onset appear to be strongly linked to a FDS diagnosis.
  • The study found significant differences in the profiles of patients with functional/dissociative seizures, epilepsy, and the co-occurrence of both conditions.
  • The findings suggest that personalized care can be offered to patients with seizure disorders by accurately differentiating clinical profiles.
  • The study was conducted by researchers from the University of Lorraine and the National Center for Scientific Research (CNRS) over a period of five years (2018-2023).
  • The study was funded by the Institute La Teppe and FFRE.
  • The research has been peer-reviewed and published in the journal Seizure.

Statistics:

  • 296 patients were analyzed in the study.
  • 195 patients had epilepsy, 66 patients had functional/dissociative seizures (FDS), and 35 patients had the co-occurrence of epilepsy and FDS.
  • The FDS-only group was more likely to be female (p=.004).
  • The FDS-only group had a later seizure onset (p<.001).
  • Sexual trauma and late seizure onset appear to be strongly linked to a FDS diagnosis (p<.001).

Sources:

  • NewsRx. New Seizures Findings Reported from University of Lorraine [Discriminating Clinical Profiles In Epilepsy, In Functional/dissociative Seizures (Fds) and Co-occurrence]. Mental Health Weekly Digest. November 3, 2025; p 440.
  • Discriminating Clinical Profiles In Epilepsy, In Functional/dissociative Seizures (Fds) and Co-occurrence. Seizure, 2025;132:110-116.

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