Association of Polymorphisms in 9p21 Region with CAD in North Indian Population Replicated

Researchers from the Institute of Genomics and Integrative Biology in Delhi, India, have replicated the association of three single nucleotide polymorphisms (SNPs) with coronary artery disease (CAD) in a North Indian population. The study, published in Clinical Genetics, found that the SNPs rs10116277, rs1333040, and rs2383206, located at the 9p21 locus, were significantly associated with CAD after controlling for various confounding factors.

Key Takeaways:

• The study replicated the association of three SNPs (rs10116277, rs1333040, and rs2383206) with CAD in a North Indian population, which has the highest incidence of CAD worldwide.
• The minor allele frequency of these six SNPs was comparable to that reported in previous genome-wide association studies (GWAS).
• The SNPs were significantly associated with CAD even after controlling for factors such as age, sex, body mass index, homocysteine, hypertension, diabetes, smoking, and diet.
• The 9p21 locus, associated with cardiovascular diseases in Caucasian populations, was also found to be significant in the North Indian population.
• The study's findings suggest that the genetic factors contributing to CAD are similar across different populations.

Statistics:

• 754 individuals (311 CAD patients and 443 controls) were recruited for the study.
• 6 SNPs (rs10116277, rs10757274, rs1333040, rs2383206, rs2383207, and rs1994016) were genotyped in the study.
• The minor allele frequency of the six SNPs was comparable to that reported in previous GWAS.
• 3 SNPs (rs10116277, rs1333040, and rs2383206) were found to be significantly associated with CAD.

Sources:

• Kumar J, et al. (2011). Association of polymorphisms in 9p21 region with CAD in North Indian population: replication of SNPs identified through GWAS. Clinical Genetics, 79(6), 588-593.
• [No additional sources mentioned in the original text]