Sign in Subscribe
Social services

Autoimmune Diseases Accelerate Chronic Cardiovascular Disease, Study Shows

Strategic Insights

— 1 min read

Researchers at the University of Minnesota have found that autoimmune diseases can accelerate the development of chronic cardiovascular disease in humans. The study, which was funded by the US Department of Health and Human Services and the National Institutes of Health, demonstrates that blocking a specific protein can reduce the risk of cardiovascular disease in people with autoimmune conditions.

Key Takeaways:

  • The study found that systemic autoantibody-mediated diseases accelerate chronic cardiovascular disease in humans.
  • In a mouse model of autoimmune arthritis, researchers found that valvular carditis arises due to Fc receptor-mediated activation of macrophages, leading to the production of pathogenic TNF and IL-6.
  • The study identified CD47 as a potential therapeutic target for reducing cardiovascular disease risk in autoimmune diseases.
  • Blocking CD47 prevented and treated valvular carditis in mice by impairing macrophage efferocytosis and enhancing cytokine production.
  • The research suggests that targeting CD47 may be a potential strategy for reducing cardiovascular disease risk in people with autoimmune conditions.

Statistics:

  • The study was funded by the US Department of Health and Human Services (HHS) and the National Institutes of Health (NIH).
  • The research was conducted on the K/B.g7 mouse model of spontaneous autoantibody-mediated inflammatory arthritis.
  • 2,643-2,651 is the journal page number range for the study "Cd47 Promotes Autoimmune Valvular Carditis By Impairing Macrophage Efferocytosis and Enhancing Cytokine Production."
  • 208(12) is the volume and issue number of The Journal of Immunology, where the study was published.
  • The study was conducted by researchers from the University of Minnesota, including Bryce A. Binstadt and Lee A. Meier.

Sources:

  • The Journal of Immunology,volume 208, issue 12, 2022, p 2,643-2,651.
  • Health & Medicine Week, August 12, 2022; p 7109.
  • Study Data from University of Minnesota Update Knowledge of Autoimmunity (Cd47 Promotes Autoimmune Valvular Carditis By Impairing Macrophage Efferocytosis and Enhancing Cytokine Production).

Read more