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Diseases

Biomarkers for Liver Cirrhosis: New Insights into Survival Rates

Strategic Insights

— 2 min read

Research conducted at the General Hospital of Northern Theater Command in Shenyang, People's Republic of China, has shed new light on the relationship between cardiovascular biomarkers and the prognosis of patients with liver cirrhosis. Scientists have found that elevated levels of high-sensitivity cardiac troponin T (hs-cTnT) and N-terminal pro-B-type natriuretic peptide (NT-ProBNP) may be associated with a higher risk of further decompensation and death in patients with liver cirrhosis.

Key Takeaways:

  • The study included 601 patients with liver cirrhosis who were consecutively admitted to the Department of Gastroenterology of the General Hospital of Northern Theater Command from June 2020 to January 2024.
  • Elevated levels of hs-cTnT 14 ng/L and NT-ProBNP 300 pg/ml were significantly associated with higher cumulative incidence of further decompensation and death in Kaplan-Meier and Nelson-Aalen curves.
  • Hs-cTnT 14 ng/L was significantly associated with increased risk of further decompensation and death in multivariate competing risk analyses (further decompensation: sHR=1.614, p = 0.012; death: sHR=2.041, p = 0.001).
  • Hs-cTnT 14 ng/L was an independent predictor of death in multivariate Cox regression analyses (HR=1.677, p = 0.017).
  • NT-ProBNP and unspecified CAD were not independently associated with further decompensation or death in multivariate competing risk and Cox regression analyses.
  • The research concluded that hs-cTnT and NT-ProBNP, rather than unspecified CAD, should be incorporated in the prognostic model of liver cirrhosis.

Statistics:

  • 601 patients with liver cirrhosis were included in the study.
  • 14 ng/L and 300 pg/ml were the cutoff values for hs-cTnT and NT-ProBNP, respectively, which were significantly associated with higher cumulative incidence of further decompensation and death.
  • The study found that 1.614 and 2.041 were the standardized hazard ratios (sHR) for further decompensation and death, respectively, associated with elevated levels of hs-cTnT 14 ng/L.
  • The hazard ratio (HR) for death associated with hs-cTnT 14 ng/L was 1.677 (p = 0.017).

Sources:

  • Digestive and Liver Disease, 2025.
  • Elsevier Science Inc, Ste 800, 230 Park Ave, New York, NY 10169, USA.
  • Yao Xiao, Dept. of Gastroenterology, General Hospital of Northern Theater Command, Shenyang, People's Republic of China.
  • Liyan Dong, Yibing Li, Yong He, Yu Liu, Xingshun Qi, and Huishan Wang, additional authors of the research.
  • NewsRx. Findings from General Hospital of Northern Theater Command Provide New Insights into Liver Cirrhosis (hs-cTnT and NT-ProBNP, rather than unspecified coronary artery disease, may be associated with further decompensation and death in liver ...). Cardiovascular Week. October 20, 2025; p 20.

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