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Nanotechnology

Biosynthesis of Metal Nanoparticles Shows Potential in Wound Healing and Antimicrobial Activities

Strategic Insights

— 1 min read

Researchers from Duy Tan University in Da Nang, Vietnam, have made a breakthrough in the biosynthesis of metal nanoparticles, which shows promise in wound healing and antimicrobial activities. The study, titled "Enhanced In Vivo Wound Healing Efficacy and Excellent Antibacterial, Antifungal, Antioxidant and Anticancer Activities Via Agnps@pcs," was published in the Arabian Journal of Chemistry. The researchers used Petroselinum crispum seed extract to prepare silver nanoparticles, which were then tested for their biological activity.

Key Takeaways:

  • The study found that the biosynthesized silver nanoparticles (AgNPs) showed excellent antimicrobial properties against fungal and bacterial strains, including MRSA.
  • The AgNPs also demonstrated significant antioxidant and anticancer activities, with an IC50 value of 200 mg/ml after a 24-hour exposure on the MCF-7 cell line.
  • The researchers found that the AgNPs accelerated wound healing by increasing the number of fibroblast cells and preventing inflammation in the wound area.
  • The study concluded that the Petroselinum crispum-mediated silver nanoparticles have potential biological activity that can be used as a nanodrug in clinical treatment.
  • The research was supported by the Birjand University of Medical Sciences and was published under the CC BY-NC-ND license.

Statistics:

  • 200 mg/ml: The IC50 value of AgNPs against the MCF-7 cell line after 24-hour exposure.
  • 420 nm: The surface plasmon response of the AgNPs.
  • 7 days: The time it took for the wound to be 50% closed with the AgNPs@PCS ointment.
  • 14 days: The time it took for the wound to be 80% closed with the AgNPs@PCS ointment.
  • 21 days: The time it took for the wound to be completely closed with the AgNPs@PCS ointment.

Sources:

  • NewsRx. Findings in the Area of Nanoparticles Reported from Duy Tan University (Enhanced In Vivo Wound Healing Efficacy and Excellent Antibacterial, Antifungal, Antioxidant and Anticancer Activities Via Agnps@pcs). Biotech Week. October 4, 2023; p 717.
  • Arabian Journal of Chemistry. Enhanced In Vivo Wound Healing Efficacy and Excellent Antibacterial, Antifungal, Antioxidant and Anticancer Activities Via Agnps@pcs. Arabian Journal of Chemistry, 2023;16(10).
  • Birjand University of Medical Sciences.
  • Duy Tan University, Institute for Research and Development, Da Nang, Vietnam.

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