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Bacterial infections

Breakthrough in Bacterial Vaccine Development: Aeromonas Salmonicida and Edwardsiella Tarda Combined Vaccine Achieves 100% Relative Percentage Survival Rate

Strategic Insights

— 1 min read

Researchers at Hunan Normal University have engineered a recombinant strain of Aeromonas salmonicida, which can deliver antigens to host cells via the type III secretion system (T3SS), making it a highly effective strategy against bacterial infections. By heterologously biosynthesizing the T3SS from Photorhabdus luminescens TT01, they created a bivalent vaccine targeting both Edwardsiella tarda and Aeromonas salmonicida. This vaccine was tested on tilapia, and the results showed a 100% relative percentage survival rate when challenged with lethal E. tarda EIB202, and also effectively colonized fish tissues without inducing pathology.

Key Takeaways:

  • Researchers at Hunan Normal University engineered a recombinant strain of Aeromonas salmonicida that can deliver antigens to host cells via the type III secretion system (T3SS).
  • The T3SS is a highly effective strategy against bacterial infections and has been used to create a bivalent vaccine targeting both Edwardsiella tarda and Aeromonas salmonicida.
  • The vaccine has been shown to be highly effective in tilapia, achieving a 100% relative percentage survival rate when challenged with lethal E. tarda EIB202.
  • The vaccine also effectively colonized fish tissues without inducing pathology.
  • The vaccine significantly enhanced innate immune enzyme activities and elevated serum IgM levels as well as proinflammatory cytokines (IL-6, TNF-alpha, IFN-alpha), and antigen-presenting cell (APC) activation.
  • This research has been peer-reviewed and published in the journal Aquaculture.
  • The authors of the study include Shengbiao Hu, Simei He, Guofan Zhang, Yuyuan Peng, Kunyan Li, Jiajie Xie, Ke Zhang, Wen Fu, Yamei Xiao, and Liqiu Xia from Hunan Normal University.
  • The research was funded by the National Key Research & Development Program of China and the National Natural Science Foundation of China (NSFC).

Statistics:

  • 100% relative percentage survival rate in tilapia challenged with lethal E. tarda EIB202.
  • 100% effective colonization of fish tissues without inducing pathology.
  • 22 researchers contributed to this study from Hunan Normal University.
  • The research was funded by 2 organizations: National Key Research & Development Program of China and National Natural Science Foundation of China (NSFC).

Sources:

  • "Bivalent Vaccination With Edwardsiella Tarda and Aeromonas Salmonicida Protected Freshwater Fish After Challenge and Consists a Strategic Approach Against Pathogens." Aquaculture, 2025;609.
  • NewsRx. Researchers at Hunan Normal University Have Reported New Data on Aeromonas salmonicida (Bivalent Vaccination With Edwardsiella Tarda and Aeromonas Salmonicida Protected Freshwater Fish After Challenge and Consists a Strategic Approach Against ...). Life Science Weekly. October 21, 2025; p 5562.

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