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Cancer

Breakthrough in Gastric Cancer Detection: Researchers Develop Innovative Sensor

Strategic Insights

— 2 min read

Researchers at Qiqihar University in China have made a significant contribution to the field of oncology, specifically in the detection of gastric cancer. By identifying p-Hydroxybenzoic acid as a crucial biomarker in urine, the team designed and synthesized a novel magnetic hollow carbon dot molecularly imprinted fluorescence sensor (Fe3O4/CDs@MIPs) that can detect this biomarker with high sensitivity and selectivity. The sensor demonstrated exceptional accuracy, reproducibility, and stability, making it a promising tool for early diagnosis and monitoring of gastric cancer.

Key Takeaways:

  • The research identified p-Hydroxybenzoic acid as a crucial biomarker for the early detection and screening of gastric cancer.
  • The novel magnetic hollow carbon dot molecularly imprinted fluorescence sensor (Fe3O4/CDs@MIPs) was designed and synthesized to achieve high sensitivity and selectivity detection of this biomarker.
  • The sensor exhibited a strong linear response within the concentration range of 0-100 mu mol/L, with an impressive detection limit of 0.37 mu mol/L.
  • The sensor demonstrated excellent specificity, showing minimal interference from common cations, anions, amino acids, and structural analogs.
  • Spike recovery experiments conducted on urine samples from both gastric cancer patients and healthy individuals revealed recovery rates ranging from 95.00 % to 106.67 % and relative standard deviations between 0.76 % and 2.80 %.
  • The sensor's outstanding accuracy, reproducibility, and stability make it a promising tool for early diagnosis and monitoring of gastric cancer.
  • The research was funded by the National Natural Science Foundation of China (NSFC), Special Scientific Research Fund of Powerful Province Through Higher Education, Fundamental Research Funds in Heilongjiang Provincial Universities, and Characteristic Discipline of Plant Foods Processing Technology Research Project.
  • The study involved researchers Haiyan Qi, Qiqihar University, Rui Jie, Xiaochen Zhu, Tao Jing, Jun Li, Yunpeng Zhao, Jinzhi Yu, and Chenyu Qi.

Statistics:

  • 95.00-106.67% recovery rates were achieved in spike recovery experiments on urine samples from gastric cancer patients and healthy individuals.
  • The relative standard deviations ranged from 0.76% to 2.80%.
  • The sensor exhibited an impressive detection limit of 0.37 μmol/L.
  • The concentration range for the sensor's linear response was 0-100 μmol/L.

Sources:

  • NewsRx. Study Findings from Qiqihar University Broaden Understanding of Gastric Cancer (Molecularly Imprinted Fluorescence Sensor Based On Fe3o4/cds@mips for Detecting the Gastric Cancer Marker P-hydroxybenzoic Acid). Health & Medicine Week. July 11, 2025; p 7436.
  • Molecularly Imprinted Fluorescence Sensor Based On Fe3o4/cds@mips for Detecting the Gastric Cancer Marker P-hydroxybenzoic Acid. Microchemical Journal, 2025;214.

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