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Cancer research

Breakthrough in Lung Cancer Treatment: Biosynthesized Silver Nanoparticles Show Promise

Strategic Insights

— 1 min read

Researchers from Davangere University in Karnataka, India, have made a significant discovery in the fight against lung cancer. According to a new study published in the journal Next Nanotechnology, they have successfully biosynthesized silver nanoparticles using the ethyl acetate extract of Aristolochia bracteolata Lam. The study reveals that these nanoparticles exhibit potent cytotoxicity against human lung adenocarcinoma cells while sparing normal cells.

Key Takeaways:

  • The study explored the green synthesis of silver nanoparticles using Aristolochia bracteolata Lam. ethyl acetate extract to evaluate their anticancer potential against human lung adenocarcinoma cells.
  • The researchers used a variety of characterization techniques, including UV-Vis spectroscopy, FTIR, XRD, zeta potential FE-SEM, and TEM, to confirm the formation and properties of the silver nanoparticles.
  • The nanoparticles exhibited a characteristic absorption peak at 450 nm and a crystalline nature, with an average size of 10 nm and a moderate stability in solution.
  • The AgNPs showed potent cytotoxicity against NCIH-460 cells (IC = 13.44 g mL^-1) while sparing normal L929 cells (IC = 196.05 g mL^-1).
  • The study concluded that biosynthesized AgNPs are promising anticancer agents capable of inducing apoptosis and disrupting cancer cell proliferation, making them potential candidates for lung cancer therapy.
  • The research was conducted by H.S. Anil Kumar and his colleagues from Davangere University, including Santosh Mallikarjun Bhavi, Sapam Riches Singh, Bothe Thokchom, Ramesh Babu Yarajarla, and D. Kotresha.

Statistics:

  • The nanoparticles exhibited an average size of 10 nm.
  • The AgNPs showed a cytotoxicity ratio of 13.44 g mL^-1 against NCIH-460 cells and 196.05 g mL^-1 against L929 cells.
  • The study used a variety of characterization techniques, including UV-Vis spectroscopy, FTIR, XRD, zeta potential FE-SEM, and TEM.

Sources:

  • Next Nanotechnology: Biosynthesis of silver nanoparticles using Aristolochia bracteolata Lam. ethyl acetate extract: Characterization and In Vitro anticancer activity against lung adenocarcinoma cells. 2025; 7: 100174.
  • A free version of this journal article is available at: https://doi-org.sdpl.idm.oclc.org/10.1016/j.nxnano.2025.100174.
  • The publisher for Next Nanotechnology is Elsevier.

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