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Genetic research

Detection of Enterohemorrhagic Escherichia coli in Urinary Tract Infections after Bladder Cancer Surgery

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— 1 min read

Researchers from the Department of Clinical Laboratory at the Chifeng City Cancer Hospital in Chifeng, People's Republic of China, have conducted a study to explore the detection of enterohemorrhagic Escherichia coli with extended-spectrum beta-lactamase (ESBLs) in patients with urinary tract infections (UTIs) after bladder cancer surgery. The study found that among 87 strains of enterohemorrhagic E coli isolated, 49 strains (56.32%) produced ESBLs. The resistance rates of these ESBL-producing E coli to cefotaxime and ampicillin were high, while the resistance rate to imipenem was low. Genotypic testing revealed that blaCTX-M-14 and bla-TEM were the main ESBL genes, with blaCTX-M-14 having the highest detection rate.

Key Takeaways:

  • The study isolated 87 strains of enterohemorrhagic E coli from patients with UTIs after bladder cancer surgery.
  • Among these strains, 49 (56.32%) were found to produce ESBLs.
  • The resistance rates of ESBL-producing E coli to cefotaxime and ampicillin were 93.88% and 97.96%, respectively.
  • The detection rate of blaCTX-M-14 was the highest at 53.06%, followed by bla-TEM at 30.61%.
  • Strains carrying the bla-TEM genotype exhibited 100% resistance rates to ampicillin and tetracycline.
  • Bladder cancer patients with postoperative complications of E coli urinary tract infection have a detection rate of 56.32% for ESBL-producing E coli.

Statistics:

  • 87 strains of enterohemorrhagic E coli were isolated during the study period.
  • 49 (56.32%) of the isolated strains produced ESBLs.
  • The resistance rate to cefotaxime was 93.88%.
  • The resistance rate to ampicillin was 97.96%.
  • The detection rate of blaCTX-M-14 was 53.06%.
  • The detection rate of bla-TEM was 30.61%.

Sources:

  • NewsRx. Department of Clinical Laboratory Reports Findings in Enterohemorrhagic Escherichia coli (Study on extended-spectrum beta-lactamases genes and drug resistance in patients with urinary tract infection of enterohemorrhagic Escherichia coli after ...). Chemicals & Chemistry. May 16, 2025; p 683.
  • Medicine, 2025;104(17).
  • Lippincott Williams & Wilkins, Two Commerce Sq, 2001 Market St, Philadelphia, PA 19103, USA.

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