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Cancer research

Early-Nasal Intervention Shows Promise in Preventing Radiation-Induced Sinusitis in Nasopharyngeal Cancer Patients

Strategic Insights

— 1 min read

Researchers from the First Affiliated Hospital of Ningbo University in Zhejiang, People's Republic of China, have conducted a study to explore the impact of early-nasal intervention on sinusitis caused by radiation therapy in patients with nasopharyngeal carcinoma (NPC). The study, published in the Ear, Nose & Throat Journal, aimed to investigate the effects of nasal treatments on sinusitis-related scores, mucociliary transport rate, and general conditions in patients undergoing intensity-modulated radiation therapy.

Key Takeaways:

  • The study involved 80 patients with NPC, randomly divided into an experimental group (n = 40) and a control group (n = 40).
  • The experimental group received nasal treatments (nasal saline irrigation, corticosteroid nasal spray, and compound menthol drops) during radiation therapy and for 6 months after therapy.
  • The control group received only compound menthol drops during radiation therapy.
  • The study found statistically-significant differences in sinusitis-related scores between the experimental and control groups after radiation therapy.
  • The researchers concluded that early-nasal intervention demonstrates significant clinical value and safety in preventing radiation-induced sinusitis in patients with NPC.

Statistics:

  • 80 patients with NPC were involved in the study.
  • 40 patients were in the experimental group and 40 patients were in the control group.
  • Statistically-significant differences in sinusitis-related scores were observed between the experimental and control groups after radiation therapy.
  • The mucociliary transport rate (MTR) was collected at different time points of radiation therapy and showed no statistically-significant differences between the two groups before radiation therapy.

Sources:

  • Clinical Study of Early-Nasal Intervention Among Individuals With Nasopharyngeal Cancer to Prevent Radiation-Induced Sinusitis. Ear, Nose & Throat Journal, 2025:1455613251347164.
  • NewsRx. First Affiliated Hospital Reports Findings in Nasopharyngeal Carcinoma (Clinical Study of Early-Nasal Intervention Among Individuals With Nasopharyngeal Cancer to Prevent Radiation-Induced Sinusitis). Chemicals & Chemistry. June 20, 2025; p 1235.

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