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Cancer research

Efficacy of Treatments for T3bN0M0 Prostate Cancer Patients Explored in Latest Research

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— 1 min read

A recent study has shed light on the efficacy of various treatments for patients with prostate cancer who have invaded the seminal vesicles without metastasis. Researchers at the Erasmus University Medical Center Cancer Institute conducted a systematic review and meta-analysis to investigate the effectiveness of treatments such as radical prostatectomy, external beam radiotherapy, brachytherapy, androgen deprivation therapy, and combinations of these treatments.

Key Takeaways:

  • The study included 25 studies comprising 2,881 patients, with the primary outcome measure being 5-year biochemical recurrence-free survival (BRFS).
  • The pooled estimated 5-year BRFS for external beam radiotherapy (EBRT) and androgen deprivation therapy (ADT) was 68%, ranging from 56% in studies on low-dose radiotherapy.
  • The study found that focal dose-escalation could be a viable option for patients with prostate cancer invading the seminal vesicles without metastasis, if proven safe.
  • Radical prostatectomy with pelvic lymphadenectomy and combinations of treatments were also found to be effective, with 5-year BRFS rates ranging from 60% to 80%.
  • A systematic review was performed according to the Cochrane guidance and reported according to the guidelines for the Preferred Reporting Items for Systematic Reviews and Meta-analyses.
  • The review protocol was registered prospectively in the PROSPERO database, and studies were selected by two independent reviewers from MEDLINE, EMBASE, and trial registries.

Statistics:

  • 25 studies were included in the meta-analysis, with a total of 2,881 patients.
  • The pooled estimated 5-year BRFS for EBRT and ADT was 68%.
  • 5-year BRFS rates for radical prostatectomy with pelvic lymphadenectomy ranged from 60% to 80%.
  • The study used a systematic review design, with two independent reviewers selecting studies from MEDLINE, EMBASE, and trial registries.

Sources:

  • Efficacy of Treatments for T3bN0M0 Prostate Cancer Patients: A Systematic Review and Meta-Analysis. The Prostate, 2025.
  • Erasmus University Medical Center Cancer Institute.

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