Sign in Subscribe
Cancer

Estrogen Receptor-b Gene Cytosine-Adenine Repeat Polymorphism Affects Colon Cancer

Strategic Insights

— 1 min read

Research conducted by a team at Toho University in Tokyo, Japan, has shed light on the relationship between estrogen receptor-b gene cytosine-adenine (ESR2-CA) repeat polymorphism and colon cancer. The study, published in the International Journal of Molecular Sciences, investigated the impact of ESR2-CA repeats on colon cancer in postmenopausal women. The researchers found that the germline ESR2-CA genotype and resulting estrogen receptor-b expression were associated with the clinical characteristics of colon cancer, including age, locus, and mismatch repair protein status.

Key Takeaways:

  • The study found that ESR2-CA repeats were present in 70% of non-cancerous tissues, but only in 30% of cancerous tissues.
  • The researchers discovered that the SS genotype of ESR2-CA was associated with a higher expression of estrogen receptor-b in non-cancerous tissues.
  • The study concluded that the germline ESR2-CA genotype and resulting estrogen receptor-b expression were considered to affect the clinical characteristics of colon cancer, including age, locus, and mismatch repair protein status.
  • A shorter allele of ESR2-CA was found to increase the risk of colon cancer in older women, while it decreased the risk in younger postmenopausal women.
  • The researchers suggested that the ESR2-CA repeat polymorphism may play a role in the development of colon cancer, particularly in postmenopausal women.

Statistics:

  • 70% of non-cancerous tissues had ESR2-CA repeats.
  • 30% of cancerous tissues had ESR2-CA repeats.
  • 70Rt cases were characterized by non-cancerous tissues with a high rate of SS genotype or high estrogen receptor-b expression.
  • The study investigated 114 postmenopausal women with and without colon cancer.

Sources:

  • International Journal of Molecular Sciences. "Estrogen Receptor-b Gene Cytosine-Adenine (ESR2-CA) Repeat Polymorphism in Postmenopausal Colon Cancer." https://doi-org.sdpl.idm.oclc.org/10.3390/ijms24054502
  • NewsRx. "Toho University Researcher Provides New Study Findings on Colon Cancer [Estrogen Receptor-b Gene Cytosine-Adenine (ESR2-CA) Repeat Polymorphism in Postmenopausal Colon Cancer]." OBGYN & Reproduction Week, March 13, 2023, p 636.

Read more